Cargando…
An Oral Fluorouracil Prodrug, Capecitabine, Mitigates a Gram-Positive Systemic Infection in Mice
New classes of antibiotics are needed to fight bacterial infections, and repurposing existing drugs as antibiotics may enable rapid deployment of new treatments. Screens for antibacterials have been traditionally performed in standard laboratory media, but bacterial pathogens experience very differe...
Autores principales: | McLeod, Jack R., Harvey, Pamela A., Detweiler, Corrella S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419118/ https://www.ncbi.nlm.nih.gov/pubmed/34190602 http://dx.doi.org/10.1128/spectrum.00275-21 |
Ejemplares similares
-
A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids
por: Dombach, Jamie L., et al.
Publicado: (2020) -
Efficacy of the Oral Fluorouracil Pro-drug Capecitabine in Cancer Treatment: a Review
por: Koukourakis, Georgios V., et al.
Publicado: (2008) -
The Biomechanisms of Metal and Metal-Oxide Nanoparticles’ Interactions with Cells
por: Teske, Sondra S., et al.
Publicado: (2015) -
A 5-Fluorouracil-Induced Hyperammonemic Encephalopathy Challenged with Capecitabine
por: Chahin, Michael, et al.
Publicado: (2020) -
Staphylococcal Bacterial Persister Cells, Biofilms, and Intracellular Infection Are Disrupted by JD1, a Membrane-Damaging Small Molecule
por: Dombach, Jamie L., et al.
Publicado: (2021)