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Non-steroidal Anti-inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study

PURPOSE: The aim of this study was to examine whether use of regular aspirin and/or other non-steroidal anti-inflammatory drugs (NSAIDs) is associated with the development of age-related macular degeneration (AMD). METHODS: In the California Teachers Study cohort (N = 88,481) we identified diagnoses...

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Autores principales: Xu, Xiaoqing, Ritz, Beate, Coleman, Anne L., Liew, Zeyan, Deapen, Dennis, Lee, Eunjung, Bernstein, Leslie, Pinder, Rich, Marshall, Sarah F., Heck, Julia E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419134/
https://www.ncbi.nlm.nih.gov/pubmed/34309807
http://dx.doi.org/10.1007/s40266-021-00885-z
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author Xu, Xiaoqing
Ritz, Beate
Coleman, Anne L.
Liew, Zeyan
Deapen, Dennis
Lee, Eunjung
Bernstein, Leslie
Pinder, Rich
Marshall, Sarah F.
Heck, Julia E.
author_facet Xu, Xiaoqing
Ritz, Beate
Coleman, Anne L.
Liew, Zeyan
Deapen, Dennis
Lee, Eunjung
Bernstein, Leslie
Pinder, Rich
Marshall, Sarah F.
Heck, Julia E.
author_sort Xu, Xiaoqing
collection PubMed
description PURPOSE: The aim of this study was to examine whether use of regular aspirin and/or other non-steroidal anti-inflammatory drugs (NSAIDs) is associated with the development of age-related macular degeneration (AMD). METHODS: In the California Teachers Study cohort (N = 88,481) we identified diagnoses of AMD up to December 31, 2012 by linkage to statewide hospital discharge records. Aspirin, ibuprofen, other NSAIDs, and acetaminophen use and comprehensive risk factor information were collected via self-administered questionnaires at baseline in 1995–1996 and a follow-up questionnaire in 2005–2006. We employed Cox proportional hazard regression to model AMD risk. RESULTS: We did not find any associations between AMD and frequency and duration of aspirin or ibuprofen use reported at baseline. In the subsample with more specific information on medication use, we observed a 20% decrease in risk of AMD among low-dose aspirin users (HR 0.81, 95% CI 0.70–0.95) and a 55% decrease among cyclooxygenase-2 (COX-2) inhibitor users (HR 0.45, 95% CI 0.26–0.78) during 6.3 years of average follow-up. CONCLUSION: The decrease in risk of intermediate- or late-stage AMD among women who reported regular use of low-dose aspirin or specific COX-2 inhibitors suggests a possible protective role for medications with COX-2 inhibitory properties or aspirin at doses used for cardiovascular disease prevention.
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spelling pubmed-84191342021-09-22 Non-steroidal Anti-inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study Xu, Xiaoqing Ritz, Beate Coleman, Anne L. Liew, Zeyan Deapen, Dennis Lee, Eunjung Bernstein, Leslie Pinder, Rich Marshall, Sarah F. Heck, Julia E. Drugs Aging Original Research Article PURPOSE: The aim of this study was to examine whether use of regular aspirin and/or other non-steroidal anti-inflammatory drugs (NSAIDs) is associated with the development of age-related macular degeneration (AMD). METHODS: In the California Teachers Study cohort (N = 88,481) we identified diagnoses of AMD up to December 31, 2012 by linkage to statewide hospital discharge records. Aspirin, ibuprofen, other NSAIDs, and acetaminophen use and comprehensive risk factor information were collected via self-administered questionnaires at baseline in 1995–1996 and a follow-up questionnaire in 2005–2006. We employed Cox proportional hazard regression to model AMD risk. RESULTS: We did not find any associations between AMD and frequency and duration of aspirin or ibuprofen use reported at baseline. In the subsample with more specific information on medication use, we observed a 20% decrease in risk of AMD among low-dose aspirin users (HR 0.81, 95% CI 0.70–0.95) and a 55% decrease among cyclooxygenase-2 (COX-2) inhibitor users (HR 0.45, 95% CI 0.26–0.78) during 6.3 years of average follow-up. CONCLUSION: The decrease in risk of intermediate- or late-stage AMD among women who reported regular use of low-dose aspirin or specific COX-2 inhibitors suggests a possible protective role for medications with COX-2 inhibitory properties or aspirin at doses used for cardiovascular disease prevention. Springer International Publishing 2021-07-26 2021 /pmc/articles/PMC8419134/ /pubmed/34309807 http://dx.doi.org/10.1007/s40266-021-00885-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Original Research Article
Xu, Xiaoqing
Ritz, Beate
Coleman, Anne L.
Liew, Zeyan
Deapen, Dennis
Lee, Eunjung
Bernstein, Leslie
Pinder, Rich
Marshall, Sarah F.
Heck, Julia E.
Non-steroidal Anti-inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study
title Non-steroidal Anti-inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study
title_full Non-steroidal Anti-inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study
title_fullStr Non-steroidal Anti-inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study
title_full_unstemmed Non-steroidal Anti-inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study
title_short Non-steroidal Anti-inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study
title_sort non-steroidal anti-inflammatory drug use and risk of age-related macular degeneration in the california teachers study
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419134/
https://www.ncbi.nlm.nih.gov/pubmed/34309807
http://dx.doi.org/10.1007/s40266-021-00885-z
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