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PTCSC3‐mediated glycolysis suppresses thyroid cancer progression via interfering with PGK1 degradation
The Warburg effect (aerobic glycolysis), a hallmark of cancer, serves as a promising target for diagnosis and therapy. Growing evidence indicates that long non‐coding RNAs (lncRNAs) play an important role in aerobic glycolysis of various tumours. However, the correlation between lncRNAs and glycolys...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419167/ https://www.ncbi.nlm.nih.gov/pubmed/34337858 http://dx.doi.org/10.1111/jcmm.16806 |
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author | Jiang, Bo Chen, Yong Xia, Fada Li, Xinying |
author_facet | Jiang, Bo Chen, Yong Xia, Fada Li, Xinying |
author_sort | Jiang, Bo |
collection | PubMed |
description | The Warburg effect (aerobic glycolysis), a hallmark of cancer, serves as a promising target for diagnosis and therapy. Growing evidence indicates that long non‐coding RNAs (lncRNAs) play an important role in aerobic glycolysis of various tumours. However, the correlation between lncRNAs and glycolysis in thyroid cancer cells is still poorly understood. In this study, we showed that lncRNA papillary thyroid cancer susceptibility candidate 3 (PTCSC3) was significantly downregulated in papillary thyroid carcinoma (PTC). Overexpression of PTCSC3 significantly inhibited the aerobic glycolysis and tumour growth of PTC cells. Consistently, PTCSC3 overexpression suppressed tumour progress in vivo. Mechanistically, PTCSC3 inhibits aerobic glycolysis and proliferation of PTC by directly interacting with PGK1, a key enzyme in glycolytic pathway. As a result, PTCSC3 performs its role in PTC development via PGK1 and may be a potential therapeutic target for PTC treatment. |
format | Online Article Text |
id | pubmed-8419167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84191672021-09-08 PTCSC3‐mediated glycolysis suppresses thyroid cancer progression via interfering with PGK1 degradation Jiang, Bo Chen, Yong Xia, Fada Li, Xinying J Cell Mol Med Original Articles The Warburg effect (aerobic glycolysis), a hallmark of cancer, serves as a promising target for diagnosis and therapy. Growing evidence indicates that long non‐coding RNAs (lncRNAs) play an important role in aerobic glycolysis of various tumours. However, the correlation between lncRNAs and glycolysis in thyroid cancer cells is still poorly understood. In this study, we showed that lncRNA papillary thyroid cancer susceptibility candidate 3 (PTCSC3) was significantly downregulated in papillary thyroid carcinoma (PTC). Overexpression of PTCSC3 significantly inhibited the aerobic glycolysis and tumour growth of PTC cells. Consistently, PTCSC3 overexpression suppressed tumour progress in vivo. Mechanistically, PTCSC3 inhibits aerobic glycolysis and proliferation of PTC by directly interacting with PGK1, a key enzyme in glycolytic pathway. As a result, PTCSC3 performs its role in PTC development via PGK1 and may be a potential therapeutic target for PTC treatment. John Wiley and Sons Inc. 2021-08-01 2021-09 /pmc/articles/PMC8419167/ /pubmed/34337858 http://dx.doi.org/10.1111/jcmm.16806 Text en © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Jiang, Bo Chen, Yong Xia, Fada Li, Xinying PTCSC3‐mediated glycolysis suppresses thyroid cancer progression via interfering with PGK1 degradation |
title | PTCSC3‐mediated glycolysis suppresses thyroid cancer progression via interfering with PGK1 degradation |
title_full | PTCSC3‐mediated glycolysis suppresses thyroid cancer progression via interfering with PGK1 degradation |
title_fullStr | PTCSC3‐mediated glycolysis suppresses thyroid cancer progression via interfering with PGK1 degradation |
title_full_unstemmed | PTCSC3‐mediated glycolysis suppresses thyroid cancer progression via interfering with PGK1 degradation |
title_short | PTCSC3‐mediated glycolysis suppresses thyroid cancer progression via interfering with PGK1 degradation |
title_sort | ptcsc3‐mediated glycolysis suppresses thyroid cancer progression via interfering with pgk1 degradation |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419167/ https://www.ncbi.nlm.nih.gov/pubmed/34337858 http://dx.doi.org/10.1111/jcmm.16806 |
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