Siglec-H-Deficient Mice Show Enhanced Type I IFN Responses, but Do Not Develop Autoimmunity After Influenza or LCMV Infections

Siglec-H is a DAP12-associated receptor on plasmacytoid dendritic cells (pDCs) and microglia. Siglec-H inhibits TLR9-induced IFN-α production by pDCs. Previously, it was found that Siglec-H-deficient mice develop a lupus-like severe autoimmune disease after persistent murine cytomegalovirus (mCMV) i...

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Detalles Bibliográficos
Autores principales: Szumilas, Nadine, Corneth, Odilia B. J., Lehmann, Christian H. K., Schmitt, Heike, Cunz, Svenia, Cullen, Jolie G., Chu, Talyn, Marosan, Anita, Mócsai, Attila, Benes, Vladimir, Zehn, Dietmar, Dudziak, Diana, Hendriks, Rudi W., Nitschke, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419311/
https://www.ncbi.nlm.nih.gov/pubmed/34497606
http://dx.doi.org/10.3389/fimmu.2021.698420

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