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Abnormal Topological Network in Parkinson’s Disease With Impulse Control Disorders: A Resting-State Functional Magnetic Resonance Imaging Study

In recent years, neuroimaging evidence shows that the brains of Parkinson disease (PD) with impulse control disorders (ICDs) patients have functional disconnection changes. However, so far, it is still unclear whether the topological organization is damaged in PD patients with ICD. In this study, we...

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Autores principales: Zhu, Xiaopeng, Liu, Langsha, Xiao, Yan, Li, Fan, Huang, Yongkai, Han, Deqing, Yang, Chun, Pan, Sian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419312/
https://www.ncbi.nlm.nih.gov/pubmed/34497483
http://dx.doi.org/10.3389/fnins.2021.651710
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author Zhu, Xiaopeng
Liu, Langsha
Xiao, Yan
Li, Fan
Huang, Yongkai
Han, Deqing
Yang, Chun
Pan, Sian
author_facet Zhu, Xiaopeng
Liu, Langsha
Xiao, Yan
Li, Fan
Huang, Yongkai
Han, Deqing
Yang, Chun
Pan, Sian
author_sort Zhu, Xiaopeng
collection PubMed
description In recent years, neuroimaging evidence shows that the brains of Parkinson disease (PD) with impulse control disorders (ICDs) patients have functional disconnection changes. However, so far, it is still unclear whether the topological organization is damaged in PD patients with ICD. In this study, we aimed to explore the functional brain network in 18 patients with PD with ICDs (PD-ICD) and 18 patients with PD without ICDs (PD-nICD) by using functional magnetic resonance imaging and graph theory approach. We found that the PD-ICD patients had increased clustering coefficient and characteristic path length, while decreased small-world index compared with PD-nICD patients. Furthermore, we explored the hypothesis whether the abnormality of the small-world network parameters of PD-ICD patients is accompanied by the change of nodal centrality. As we hypothesized, the nodal centralities of the default mode network, control network, and dorsal attention network were found to be significantly damaged in the PD-ICD group compared with the PD-nICD group. Our study provides more evidence for PD-ICD patients’ brain network abnormalities from the perspective of information exchange, which may be the underlying pathophysiological basis of brain abnormalities in PD-ICD patients.
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spelling pubmed-84193122021-09-07 Abnormal Topological Network in Parkinson’s Disease With Impulse Control Disorders: A Resting-State Functional Magnetic Resonance Imaging Study Zhu, Xiaopeng Liu, Langsha Xiao, Yan Li, Fan Huang, Yongkai Han, Deqing Yang, Chun Pan, Sian Front Neurosci Neuroscience In recent years, neuroimaging evidence shows that the brains of Parkinson disease (PD) with impulse control disorders (ICDs) patients have functional disconnection changes. However, so far, it is still unclear whether the topological organization is damaged in PD patients with ICD. In this study, we aimed to explore the functional brain network in 18 patients with PD with ICDs (PD-ICD) and 18 patients with PD without ICDs (PD-nICD) by using functional magnetic resonance imaging and graph theory approach. We found that the PD-ICD patients had increased clustering coefficient and characteristic path length, while decreased small-world index compared with PD-nICD patients. Furthermore, we explored the hypothesis whether the abnormality of the small-world network parameters of PD-ICD patients is accompanied by the change of nodal centrality. As we hypothesized, the nodal centralities of the default mode network, control network, and dorsal attention network were found to be significantly damaged in the PD-ICD group compared with the PD-nICD group. Our study provides more evidence for PD-ICD patients’ brain network abnormalities from the perspective of information exchange, which may be the underlying pathophysiological basis of brain abnormalities in PD-ICD patients. Frontiers Media S.A. 2021-08-23 /pmc/articles/PMC8419312/ /pubmed/34497483 http://dx.doi.org/10.3389/fnins.2021.651710 Text en Copyright © 2021 Zhu, Liu, Xiao, Li, Huang, Han, Yang and Pan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhu, Xiaopeng
Liu, Langsha
Xiao, Yan
Li, Fan
Huang, Yongkai
Han, Deqing
Yang, Chun
Pan, Sian
Abnormal Topological Network in Parkinson’s Disease With Impulse Control Disorders: A Resting-State Functional Magnetic Resonance Imaging Study
title Abnormal Topological Network in Parkinson’s Disease With Impulse Control Disorders: A Resting-State Functional Magnetic Resonance Imaging Study
title_full Abnormal Topological Network in Parkinson’s Disease With Impulse Control Disorders: A Resting-State Functional Magnetic Resonance Imaging Study
title_fullStr Abnormal Topological Network in Parkinson’s Disease With Impulse Control Disorders: A Resting-State Functional Magnetic Resonance Imaging Study
title_full_unstemmed Abnormal Topological Network in Parkinson’s Disease With Impulse Control Disorders: A Resting-State Functional Magnetic Resonance Imaging Study
title_short Abnormal Topological Network in Parkinson’s Disease With Impulse Control Disorders: A Resting-State Functional Magnetic Resonance Imaging Study
title_sort abnormal topological network in parkinson’s disease with impulse control disorders: a resting-state functional magnetic resonance imaging study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419312/
https://www.ncbi.nlm.nih.gov/pubmed/34497483
http://dx.doi.org/10.3389/fnins.2021.651710
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