Ascorbate Inhibits Proliferation and Promotes Myeloid Differentiation in TP53-Mutant Leukemia

Loss-of-function mutations in the DNA demethylase TET2 are associated with the dysregulation of hematopoietic stem cell differentiation and arise in approximately 10% of de novo acute myeloid leukemia (AML). TET2 mutations coexist with other mutations in AML, including TP53 mutations, which can indi...

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Detalles Bibliográficos
Autores principales: Smith-Díaz, Carlos C., Magon, Nicholas J., McKenzie, Judith L., Hampton, Mark B., Vissers, Margreet C. M., Das, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419345/
https://www.ncbi.nlm.nih.gov/pubmed/34497762
http://dx.doi.org/10.3389/fonc.2021.709543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419345/
https://www.ncbi.nlm.nih.gov/pubmed/34497762
http://dx.doi.org/10.3389/fonc.2021.709543

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