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An Inhibitory Medial Preoptic Circuit Mediates Innate Exploration
Animals have an innate motivation to explore objects and environments with unknown values. To this end, they need to activate neural pathways that enable exploration. Here, we reveal that photostimulation of a subset of medial preoptic area (MPA) neurons expressing the vesicular-GABA transporter gen...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419349/ https://www.ncbi.nlm.nih.gov/pubmed/34497488 http://dx.doi.org/10.3389/fnins.2021.716147 |
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author | Ryoo, Jia Park, Seahyung Kim, Daesoo |
author_facet | Ryoo, Jia Park, Seahyung Kim, Daesoo |
author_sort | Ryoo, Jia |
collection | PubMed |
description | Animals have an innate motivation to explore objects and environments with unknown values. To this end, they need to activate neural pathways that enable exploration. Here, we reveal that photostimulation of a subset of medial preoptic area (MPA) neurons expressing the vesicular-GABA transporter gene (vgat+) and sending axonal projections to the ventrolateral periaqueductal gray (vPAG) increases exploration in a chamber but causes no place preference when tested there without photostimulation. Photoinhibition of MPA(vgat)–vPAG projections leads to no emotional changes as measured by normal activity in an open field assay. Electrophysiological recordings revealed that most GABAergic vPAG neurons are inhibited by MPA(vgat) neurons. In contrast to a previous report that suggested that MPA(vgat)–vPAG neurons may impart positive valence to induce place preference, our results suggest that these neurons can increase innate exploration. |
format | Online Article Text |
id | pubmed-8419349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84193492021-09-07 An Inhibitory Medial Preoptic Circuit Mediates Innate Exploration Ryoo, Jia Park, Seahyung Kim, Daesoo Front Neurosci Neuroscience Animals have an innate motivation to explore objects and environments with unknown values. To this end, they need to activate neural pathways that enable exploration. Here, we reveal that photostimulation of a subset of medial preoptic area (MPA) neurons expressing the vesicular-GABA transporter gene (vgat+) and sending axonal projections to the ventrolateral periaqueductal gray (vPAG) increases exploration in a chamber but causes no place preference when tested there without photostimulation. Photoinhibition of MPA(vgat)–vPAG projections leads to no emotional changes as measured by normal activity in an open field assay. Electrophysiological recordings revealed that most GABAergic vPAG neurons are inhibited by MPA(vgat) neurons. In contrast to a previous report that suggested that MPA(vgat)–vPAG neurons may impart positive valence to induce place preference, our results suggest that these neurons can increase innate exploration. Frontiers Media S.A. 2021-08-23 /pmc/articles/PMC8419349/ /pubmed/34497488 http://dx.doi.org/10.3389/fnins.2021.716147 Text en Copyright © 2021 Ryoo, Park and Kim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Ryoo, Jia Park, Seahyung Kim, Daesoo An Inhibitory Medial Preoptic Circuit Mediates Innate Exploration |
title | An Inhibitory Medial Preoptic Circuit Mediates Innate Exploration |
title_full | An Inhibitory Medial Preoptic Circuit Mediates Innate Exploration |
title_fullStr | An Inhibitory Medial Preoptic Circuit Mediates Innate Exploration |
title_full_unstemmed | An Inhibitory Medial Preoptic Circuit Mediates Innate Exploration |
title_short | An Inhibitory Medial Preoptic Circuit Mediates Innate Exploration |
title_sort | inhibitory medial preoptic circuit mediates innate exploration |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419349/ https://www.ncbi.nlm.nih.gov/pubmed/34497488 http://dx.doi.org/10.3389/fnins.2021.716147 |
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