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Lipid Profiles in Primary Aldosteronism Compared with Essential Hypertension: Propensity-Score Matching Study

BACKGROUND: There has been controversy regarding the association between primary aldosteronism (PA) and dyslipidemia and few studies considered the effects of diabetes and renal function on lipid metabolism. We analyzed lipid profiles of PA patients and compared them to propensity-score (PS)-matched...

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Autores principales: Moon, Sun Joon, Jang, Han Na, Kim, Jung Hee, Moon, Min Kyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Endocrine Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419600/
https://www.ncbi.nlm.nih.gov/pubmed/34372626
http://dx.doi.org/10.3803/EnM.2021.1012
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author Moon, Sun Joon
Jang, Han Na
Kim, Jung Hee
Moon, Min Kyong
author_facet Moon, Sun Joon
Jang, Han Na
Kim, Jung Hee
Moon, Min Kyong
author_sort Moon, Sun Joon
collection PubMed
description BACKGROUND: There has been controversy regarding the association between primary aldosteronism (PA) and dyslipidemia and few studies considered the effects of diabetes and renal function on lipid metabolism. We analyzed lipid profiles of PA patients and compared them to propensity-score (PS)-matched essential hypertension (EH) patients adjusting for glycemic status and renal function. METHODS: Patients who were diagnosed with PA using a saline-infusion test at Seoul National University Hospital from 2000 to 2018 were retrospectively analyzed. EH patients who had aldosterone-renin ratio (ARR) results were selected as controls. Covariates, including diabetes, were PS-matched for patients with PA, lateralized PA, non-lateralized PA, and high ARR to EH patients, respectively. RESULTS: Among a total of 80 PA and 80 EH patients, total cholesterol (TC) and triglyceride (TG) levels were significantly lower in the PA patients than in the EH patients (least-squares mean±standard error: 185.5±4.4 mg/dL vs. 196.2±4.4 mg/dL, P=0.047, for TC; and 132.3±11.5 mg/dL vs. 157.4±11.4 mg/dL, P=0.035, for TG) in fully adjusted model (adjusting for multiple covariates, including diabetes status, glycosylated hemoglobin level, and estimated glomerular filtration rate). There were no significant differences in high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol levels between the two groups. According to increments in aldosterone levels, an increasing tendency of HDL-C and decreasing tendencies of TG and non-HDL-C were observed. CONCLUSION: PA patients had lower TC and TG levels than EH patients, independent of glycemic status and renal function.
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spelling pubmed-84196002021-09-14 Lipid Profiles in Primary Aldosteronism Compared with Essential Hypertension: Propensity-Score Matching Study Moon, Sun Joon Jang, Han Na Kim, Jung Hee Moon, Min Kyong Endocrinol Metab (Seoul) Original Article BACKGROUND: There has been controversy regarding the association between primary aldosteronism (PA) and dyslipidemia and few studies considered the effects of diabetes and renal function on lipid metabolism. We analyzed lipid profiles of PA patients and compared them to propensity-score (PS)-matched essential hypertension (EH) patients adjusting for glycemic status and renal function. METHODS: Patients who were diagnosed with PA using a saline-infusion test at Seoul National University Hospital from 2000 to 2018 were retrospectively analyzed. EH patients who had aldosterone-renin ratio (ARR) results were selected as controls. Covariates, including diabetes, were PS-matched for patients with PA, lateralized PA, non-lateralized PA, and high ARR to EH patients, respectively. RESULTS: Among a total of 80 PA and 80 EH patients, total cholesterol (TC) and triglyceride (TG) levels were significantly lower in the PA patients than in the EH patients (least-squares mean±standard error: 185.5±4.4 mg/dL vs. 196.2±4.4 mg/dL, P=0.047, for TC; and 132.3±11.5 mg/dL vs. 157.4±11.4 mg/dL, P=0.035, for TG) in fully adjusted model (adjusting for multiple covariates, including diabetes status, glycosylated hemoglobin level, and estimated glomerular filtration rate). There were no significant differences in high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol levels between the two groups. According to increments in aldosterone levels, an increasing tendency of HDL-C and decreasing tendencies of TG and non-HDL-C were observed. CONCLUSION: PA patients had lower TC and TG levels than EH patients, independent of glycemic status and renal function. Korean Endocrine Society 2021-08 2021-08-10 /pmc/articles/PMC8419600/ /pubmed/34372626 http://dx.doi.org/10.3803/EnM.2021.1012 Text en Copyright © 2021 Korean Endocrine Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Moon, Sun Joon
Jang, Han Na
Kim, Jung Hee
Moon, Min Kyong
Lipid Profiles in Primary Aldosteronism Compared with Essential Hypertension: Propensity-Score Matching Study
title Lipid Profiles in Primary Aldosteronism Compared with Essential Hypertension: Propensity-Score Matching Study
title_full Lipid Profiles in Primary Aldosteronism Compared with Essential Hypertension: Propensity-Score Matching Study
title_fullStr Lipid Profiles in Primary Aldosteronism Compared with Essential Hypertension: Propensity-Score Matching Study
title_full_unstemmed Lipid Profiles in Primary Aldosteronism Compared with Essential Hypertension: Propensity-Score Matching Study
title_short Lipid Profiles in Primary Aldosteronism Compared with Essential Hypertension: Propensity-Score Matching Study
title_sort lipid profiles in primary aldosteronism compared with essential hypertension: propensity-score matching study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419600/
https://www.ncbi.nlm.nih.gov/pubmed/34372626
http://dx.doi.org/10.3803/EnM.2021.1012
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