A Comprehensive Analysis of Metabolomics and Transcriptomics Reveals Novel Biomarkers and Mechanistic Insights on Lorlatinib Crosses the Blood-Brain Barrier

Of late, lorlatinib has played an increasingly pivotal role in the treatment of brain metastasis from non-small cell lung cancer. However, its pharmacokinetics in the brain and the mechanism of entry are still controversial. The purpose of this study was to explore the mechanisms of brain penetratio...

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Detalles Bibliográficos
Autores principales: Chen, Wei, Li, Chunyu, Shi, Yafei, Zhang, Yujun, Jin, Dujia, Zhang, Mingyu, Bo, Mingming, Li, Guohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419651/
https://www.ncbi.nlm.nih.gov/pubmed/34497521
http://dx.doi.org/10.3389/fphar.2021.722627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419651/
https://www.ncbi.nlm.nih.gov/pubmed/34497521
http://dx.doi.org/10.3389/fphar.2021.722627

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