N‐acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages

Glutaminolysis is known to correlate with ovarian cancer aggressiveness and invasion. However, how this affects the tumor microenvironment is elusive. Here, we show that ovarian cancer cells become addicted to extracellular glutamine when silenced for glutamine synthetase (GS), similar to naturally...

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Detalles Bibliográficos
Autores principales: Menga, Alessio, Favia, Maria, Spera, Iolanda, Vegliante, Maria C, Gissi, Rosanna, De Grassi, Anna, Laera, Luna, Campanella, Annalisa, Gerbino, Andrea, Carrà, Giovanna, Canton, Marcella, Loizzi, Vera, Pierri, Ciro L, Cormio, Gennaro, Mazzone, Massimiliano, Castegna, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419692/
https://www.ncbi.nlm.nih.gov/pubmed/34260142
http://dx.doi.org/10.15252/embr.202051981

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