Cargando…

ELAC2/RNaseZ-linked cardiac hypertrophy in Drosophila melanogaster

A severe form of infantile cardiomyopathy (CM) has been linked to mutations in ELAC2, a highly conserved human gene. It encodes Zinc phosphodiesterase ELAC protein 2 (ELAC2), which plays an essential role in the production of mature tRNAs. To establish a causal connection between ELAC2 variants and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Migunova, Ekaterina, Theophilopoulos, Joanna, Mercadante, Marisa, Men, Jing, Zhou, Chao, Dubrovsky, Edward B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419712/ https://www.ncbi.nlm.nih.gov/pubmed/34338278 http://dx.doi.org/10.1242/dmm.048931

Ejemplares similares

Cardiac RNase Z edited via CRISPR-Cas9 drives heart hypertrophy in Drosophila
por: Migunova, Ekaterina, et al.
Publicado: (2023)

Knockout of Drosophila RNase Z(L) impairs mitochondrial transcript processing, respiration and cell cycle progression
por: Xie, Xie, et al.
Publicado: (2015)

Localization of Human RNase Z Isoforms: Dual Nuclear/Mitochondrial Targeting of the ELAC2 Gene Product by Alternative Translation Initiation
por: Rossmanith, Walter
Publicado: (2011)

Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z
por: Chen, Yang, et al.
Publicado: (2005)

An RNase-sensitive particle containing Drosophila melanogaster DNA topoisomerase II
Publicado: (1994)

A survey of green plant tRNA 3'-end processing enzyme tRNase Zs, homologs of the candidate prostate cancer susceptibility protein ELAC2
por: Fan, Lijuan, et al.
Publicado: (2011)

Identification and analysis of candidate fungal tRNA 3'-end processing endonucleases tRNase Zs, homologs of the putative prostate cancer susceptibility protein ELAC2
por: Zhao, Wei, et al.
Publicado: (2010)

Chorea, psychosis, acanthocytosis, and prolonged survival associated with ELAC2 mutations
por: Paucar, Martin, et al.
Publicado: (2018)

Phylogenetic Analyses and Characterization of RNase X25 from Drosophila melanogaster Suggest a Conserved Housekeeping Role and Additional Functions for RNase T2 Enzymes in Protostomes
por: Ambrosio, Linda, et al.
Publicado: (2014)

Tethered Domains and Flexible Regions in tRNase Z(L), the Long Form of tRNase Z
por: Wilson, Christopher, et al.
Publicado: (2013)

Reproducibility of horizontal closed orbits (present status), Run 836 R1 ELAC, 26 GeV/c, Run 863 R1 ELAC/VAC, 26 GeV/c
por: Lewis, D M
Publicado: (1977)

The Function of Lipin in the Wing Development of Drosophila melanogaster
por: Duy Binh, Tran, et al.
Publicado: (2019)

Characterization of components of Z-bands in the fibrillar flight muscle of Drosophila melanogaster
Publicado: (1989)

Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy
por: Schroeder, Cornelia, et al.
Publicado: (2019)

Drosophila Melanogaster
por: Wixon, Jo, et al.
Publicado: (2000)

Circadian Regulation of Glutathione Levels and Biosynthesis in Drosophila melanogaster
por: Beaver, Laura M., et al.
Publicado: (2012)

HPC2/ELAC2 polymorphisms and prostate cancer risk: analysis by age of onset of disease
por: Meitz, J C, et al.
Publicado: (2002)

ELAC2 Functions as a Key Gene in the Early Development of Placental Formation Based on WGCNA
por: Liang, Junyong, et al.
Publicado: (2023)

Menin Links the Stress Response to Genome Stability in Drosophila melanogaster
por: Papaconstantinou, Maria, et al.
Publicado: (2010)

Yeast mitochondrial RNase P, RNase Z and the RNA degradosome are part of a stable supercomplex
por: Daoud, Rachid, et al.
Publicado: (2012)

The Sexually Antagonistic Genes of Drosophila melanogaster
por: Innocenti, Paolo, et al.
Publicado: (2010)

Role of Serotonin Transporter in Eye Development of Drosophila melanogaster
por: Pham, Tuan L. A., et al.
Publicado: (2020)

Mutations in ELAC2 associated with hypertrophic cardiomyopathy impair mitochondrial tRNA 3′‐end processing
por: Saoura, Makenzie, et al.
Publicado: (2019)

Novel ELAC2 Mutations in Individuals Presenting with Variably Severe Neurological Disease in the Presence or Absence of Cardiomyopathy
por: Cafournet, Cérane, et al.
Publicado: (2023)

Substitutions in conserved regions preceding and within the linker affect activity and flexibility of tRNase Z(L), the long form of tRNase Z
por: Saoura, Makenzie, et al.
Publicado: (2017)

Modeling Congenital Disorders of N-Linked Glycoprotein Glycosylation in Drosophila melanogaster
por: Frappaolo, Anna, et al.
Publicado: (2018)

The Influence of Chromosomal Environment on X-Linked Gene Expression in Drosophila melanogaster
por: Belyi, Aleksei, et al.
Publicado: (2020)

Geroprotective and Radioprotective Activity of Quercetin, (-)-Epicatechin, and Ibuprofen in Drosophila melanogaster
por: Proshkina, Ekaterina, et al.
Publicado: (2016)

Control of Dendritic Morphogenesis by Trio in Drosophila melanogaster
por: Shivalkar, Madhuri, et al.
Publicado: (2012)

Variation in Male Mate Choice in Drosophila melanogaster
por: Edward, Dominic A., et al.
Publicado: (2013)

The Chromosomal Proteins JIL-1 and Z4/Putzig Regulate the Telomeric Chromatin in Drosophila melanogaster
por: Silva-Sousa, Rute, et al.
Publicado: (2012)

ELAC2 polymorphisms and prostate cancer risk: a meta-analysis based on 18 case–control studies
por: Xu, B, et al.
Publicado: (2010)

Effects of unpaired 1 gene overexpression on the lifespan of Drosophila melanogaster
por: Moskalev, Alexey, et al.
Publicado: (2019)

A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster
por: Haynes, Paula R, et al.
Publicado: (2015)

The Drosophila melanogaster Cajal body
por: Liu, Ji-Long, et al.
Publicado: (2006)

Multiple actins in drosophila melanogaster
por: Horovitch, SJ, et al.
Publicado: (1979)

The developmental transcriptome of Drosophila melanogaster
por: Graveley, Brenton
Publicado: (2010)

The Drosophila melanogaster host model
por: Igboin, Christina O., et al.
Publicado: (2012)

Isolation of Drosophila melanogaster Testes
por: Zamore, Phillip D., et al.
Publicado: (2011)

The Developmental Transcriptome of Drosophila melanogaster
por: Graveley, Brenton R., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ouepmsuv2m1a9bflimlbv9ejao