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Brain and heart‐specific death in cancer patients: Population‐based study

BACKGROUND: The occurrence of cardiovascular events is a major cause of death in patients with cancer. Small studies have documented a connection between specific brain alterations and autonomic cardiac dysfunctions, possibly resulting in a worse prognosis. We aimed to refine the knowledge of fatal...

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Autores principales: Safi, Mohammed, Al‐Nusaif, Murad, Trapani, Dario, Mashrah, Mubarak A, Kanesvaran, Ravindran, Alzandani, Aziz, Al‐Azab, Mahmoud, Mazher, Syed A, Al‐Danakh, Abdullah, Liu, Jiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419745/
https://www.ncbi.nlm.nih.gov/pubmed/34374226
http://dx.doi.org/10.1002/cam4.4069
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author Safi, Mohammed
Al‐Nusaif, Murad
Trapani, Dario
Mashrah, Mubarak A
Kanesvaran, Ravindran
Alzandani, Aziz
Al‐Azab, Mahmoud
Mazher, Syed A
Al‐Danakh, Abdullah
Liu, Jiwei
author_facet Safi, Mohammed
Al‐Nusaif, Murad
Trapani, Dario
Mashrah, Mubarak A
Kanesvaran, Ravindran
Alzandani, Aziz
Al‐Azab, Mahmoud
Mazher, Syed A
Al‐Danakh, Abdullah
Liu, Jiwei
author_sort Safi, Mohammed
collection PubMed
description BACKGROUND: The occurrence of cardiovascular events is a major cause of death in patients with cancer. Small studies have documented a connection between specific brain alterations and autonomic cardiac dysfunctions, possibly resulting in a worse prognosis. We aimed to refine the knowledge of fatal cardiac events in patients with brain metastasis (BM). METHODS: We performed a Surveillance, Epidemiology, and End Results SEER registry‐based investigation (timeline: 2010–2016) and extracted all the advanced patients who had experienced fatal cardiac outcomes. Populations were compared according to the presence or not BM. Kaplan–Meier (KM) methodology was used for survival analysis and a multivariate model was developed by adjusting for multiple possible confounders. RESULTS: Most related BM and cardiac death were observed at the site of lung cancer (81.4%). We extracted 3187 patients with lung cancer site, including 417 patients who had experienced fatal heart‐specific with a history of BM, which is considered a BM group. The second group of heart‐specific death included 2770 patients was stated as a non‐BM group. Patients who had experienced heart‐specific death in the BM group were predominately male, right side, upper site, and non‐small type (62.11%, 54.92%, 51.56%, 69.78%), respectively. The survival outcomes between BM and the non‐ BM was significantly prominent (p = 0.003; median: 2 months vs. 3 months).The negative prognostic independent significance of heart‐fatal events was confirmed after adjusting for multiple variables (HR = 0.76, CI = 0.68–84, p < 0.0001). The metastatic liver site was significantly associated with poorer survival rates (HR = 0.68; CI = 0.52–0.88, p = 0.005). We revealed a possible connection between the brain and heart functions. CONCLUSIONS: The prognosis of heart‐specific death patients in BM is unfavorable compared to non‐BM settings in lung cancer. We may be at the gates of a new field of neurocardiooncology.
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spelling pubmed-84197452021-09-08 Brain and heart‐specific death in cancer patients: Population‐based study Safi, Mohammed Al‐Nusaif, Murad Trapani, Dario Mashrah, Mubarak A Kanesvaran, Ravindran Alzandani, Aziz Al‐Azab, Mahmoud Mazher, Syed A Al‐Danakh, Abdullah Liu, Jiwei Cancer Med Clinical Cancer Research BACKGROUND: The occurrence of cardiovascular events is a major cause of death in patients with cancer. Small studies have documented a connection between specific brain alterations and autonomic cardiac dysfunctions, possibly resulting in a worse prognosis. We aimed to refine the knowledge of fatal cardiac events in patients with brain metastasis (BM). METHODS: We performed a Surveillance, Epidemiology, and End Results SEER registry‐based investigation (timeline: 2010–2016) and extracted all the advanced patients who had experienced fatal cardiac outcomes. Populations were compared according to the presence or not BM. Kaplan–Meier (KM) methodology was used for survival analysis and a multivariate model was developed by adjusting for multiple possible confounders. RESULTS: Most related BM and cardiac death were observed at the site of lung cancer (81.4%). We extracted 3187 patients with lung cancer site, including 417 patients who had experienced fatal heart‐specific with a history of BM, which is considered a BM group. The second group of heart‐specific death included 2770 patients was stated as a non‐BM group. Patients who had experienced heart‐specific death in the BM group were predominately male, right side, upper site, and non‐small type (62.11%, 54.92%, 51.56%, 69.78%), respectively. The survival outcomes between BM and the non‐ BM was significantly prominent (p = 0.003; median: 2 months vs. 3 months).The negative prognostic independent significance of heart‐fatal events was confirmed after adjusting for multiple variables (HR = 0.76, CI = 0.68–84, p < 0.0001). The metastatic liver site was significantly associated with poorer survival rates (HR = 0.68; CI = 0.52–0.88, p = 0.005). We revealed a possible connection between the brain and heart functions. CONCLUSIONS: The prognosis of heart‐specific death patients in BM is unfavorable compared to non‐BM settings in lung cancer. We may be at the gates of a new field of neurocardiooncology. John Wiley and Sons Inc. 2021-08-10 /pmc/articles/PMC8419745/ /pubmed/34374226 http://dx.doi.org/10.1002/cam4.4069 Text en © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Safi, Mohammed
Al‐Nusaif, Murad
Trapani, Dario
Mashrah, Mubarak A
Kanesvaran, Ravindran
Alzandani, Aziz
Al‐Azab, Mahmoud
Mazher, Syed A
Al‐Danakh, Abdullah
Liu, Jiwei
Brain and heart‐specific death in cancer patients: Population‐based study
title Brain and heart‐specific death in cancer patients: Population‐based study
title_full Brain and heart‐specific death in cancer patients: Population‐based study
title_fullStr Brain and heart‐specific death in cancer patients: Population‐based study
title_full_unstemmed Brain and heart‐specific death in cancer patients: Population‐based study
title_short Brain and heart‐specific death in cancer patients: Population‐based study
title_sort brain and heart‐specific death in cancer patients: population‐based study
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419745/
https://www.ncbi.nlm.nih.gov/pubmed/34374226
http://dx.doi.org/10.1002/cam4.4069
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