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Combining malaria vaccination with chemoprevention: a promising new approach to malaria control

Malaria control has stalled in a number of African countries and novel approaches to malaria control are needed for these areas. The encouraging results of a recent trial conducted in young children in Burkina Faso and Mali in which a combination of the RTS,S/AS01(E) malaria vaccine and seasonal mal...

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Autores principales: Greenwood, Brian, Cairns, Matthew, Chaponda, Mike, Chico, R. Matthew, Dicko, Alassane, Ouedraogo, Jean-Bosco, Phiri, Kamija S., ter Kuile, Feiko O., Chandramohan, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419817/
https://www.ncbi.nlm.nih.gov/pubmed/34488784
http://dx.doi.org/10.1186/s12936-021-03888-8
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author Greenwood, Brian
Cairns, Matthew
Chaponda, Mike
Chico, R. Matthew
Dicko, Alassane
Ouedraogo, Jean-Bosco
Phiri, Kamija S.
ter Kuile, Feiko O.
Chandramohan, Daniel
author_facet Greenwood, Brian
Cairns, Matthew
Chaponda, Mike
Chico, R. Matthew
Dicko, Alassane
Ouedraogo, Jean-Bosco
Phiri, Kamija S.
ter Kuile, Feiko O.
Chandramohan, Daniel
author_sort Greenwood, Brian
collection PubMed
description Malaria control has stalled in a number of African countries and novel approaches to malaria control are needed for these areas. The encouraging results of a recent trial conducted in young children in Burkina Faso and Mali in which a combination of the RTS,S/AS01(E) malaria vaccine and seasonal malaria chemoprevention led to a substantial reduction in clinical cases of malaria, severe malaria, and malaria deaths compared with the administration of either intervention given alone suggests that there may be other epidemiological/clinical situations in which a combination of malaria vaccination and chemoprevention could be beneficial. Some of these potential opportunities are considered in this paper. These include combining vaccination with intermittent preventive treatment of malaria in infants, with intermittent preventive treatment of malaria in pregnancy (through vaccination of women of child-bearing age before or during pregnancy), or with post-discharge malaria chemoprevention in the management of children recently admitted to hospital with severe anaemia. Other potential uses of the combination are prevention of malaria in children at particular risk from the adverse effects of clinical malaria, such as those with sickle cell disease, and during the final stages of a malaria elimination programme when vaccination could be combined with repeated rounds of mass drug administration. The combination of a pre-erythrocytic stage malaria vaccine with an effective chemopreventive regimen could make a valuable contribution to malaria control and elimination in a variety of clinical or epidemiological situations, and the potential of this approach to malaria control needs to be explored.
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spelling pubmed-84198172021-09-07 Combining malaria vaccination with chemoprevention: a promising new approach to malaria control Greenwood, Brian Cairns, Matthew Chaponda, Mike Chico, R. Matthew Dicko, Alassane Ouedraogo, Jean-Bosco Phiri, Kamija S. ter Kuile, Feiko O. Chandramohan, Daniel Malar J Commentary Malaria control has stalled in a number of African countries and novel approaches to malaria control are needed for these areas. The encouraging results of a recent trial conducted in young children in Burkina Faso and Mali in which a combination of the RTS,S/AS01(E) malaria vaccine and seasonal malaria chemoprevention led to a substantial reduction in clinical cases of malaria, severe malaria, and malaria deaths compared with the administration of either intervention given alone suggests that there may be other epidemiological/clinical situations in which a combination of malaria vaccination and chemoprevention could be beneficial. Some of these potential opportunities are considered in this paper. These include combining vaccination with intermittent preventive treatment of malaria in infants, with intermittent preventive treatment of malaria in pregnancy (through vaccination of women of child-bearing age before or during pregnancy), or with post-discharge malaria chemoprevention in the management of children recently admitted to hospital with severe anaemia. Other potential uses of the combination are prevention of malaria in children at particular risk from the adverse effects of clinical malaria, such as those with sickle cell disease, and during the final stages of a malaria elimination programme when vaccination could be combined with repeated rounds of mass drug administration. The combination of a pre-erythrocytic stage malaria vaccine with an effective chemopreventive regimen could make a valuable contribution to malaria control and elimination in a variety of clinical or epidemiological situations, and the potential of this approach to malaria control needs to be explored. BioMed Central 2021-09-06 /pmc/articles/PMC8419817/ /pubmed/34488784 http://dx.doi.org/10.1186/s12936-021-03888-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Commentary
Greenwood, Brian
Cairns, Matthew
Chaponda, Mike
Chico, R. Matthew
Dicko, Alassane
Ouedraogo, Jean-Bosco
Phiri, Kamija S.
ter Kuile, Feiko O.
Chandramohan, Daniel
Combining malaria vaccination with chemoprevention: a promising new approach to malaria control
title Combining malaria vaccination with chemoprevention: a promising new approach to malaria control
title_full Combining malaria vaccination with chemoprevention: a promising new approach to malaria control
title_fullStr Combining malaria vaccination with chemoprevention: a promising new approach to malaria control
title_full_unstemmed Combining malaria vaccination with chemoprevention: a promising new approach to malaria control
title_short Combining malaria vaccination with chemoprevention: a promising new approach to malaria control
title_sort combining malaria vaccination with chemoprevention: a promising new approach to malaria control
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419817/
https://www.ncbi.nlm.nih.gov/pubmed/34488784
http://dx.doi.org/10.1186/s12936-021-03888-8
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