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Computational Redesign of an ω-Transaminase from Pseudomonas jessenii for Asymmetric Synthesis of Enantiopure Bulky Amines

[Image: see text] ω-Transaminases (ω-TA) are attractive biocatalysts for the production of chiral amines from prochiral ketones via asymmetric synthesis. However, the substrate scope of ω-TAs is usually limited due to steric hindrance at the active site pockets. We explored a protein engineering str...

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Detalles Bibliográficos
Autores principales:	Meng, Qinglong, Ramírez-Palacios, Carlos, Capra, Nikolas, Hooghwinkel, Mattijs E., Thallmair, Sebastian, Rozeboom, Henriëtte J., Thunnissen, Andy-Mark W. H., Wijma, Hein J., Marrink, Siewert J., Janssen, Dick B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419838/ https://www.ncbi.nlm.nih.gov/pubmed/34504735 http://dx.doi.org/10.1021/acscatal.1c02053

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