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Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens

PURPOSE: Soft contact lenses (SCLs) are effective for refractive error correction, but prolonged wear triggers discomfort and discontinuation. This study investigates whether water gradient technology of delefilcon A-based SCLs improve tear film dynamics. METHODS: This retrospective observational st...

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Autores principales: Fujimoto, Hisataka, Ochi, Shintaro, Yamashita, Tsutomu, Inoue, Yasushi, Kiryu, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419878/
https://www.ncbi.nlm.nih.gov/pubmed/34473222
http://dx.doi.org/10.1167/tvst.10.11.5
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author Fujimoto, Hisataka
Ochi, Shintaro
Yamashita, Tsutomu
Inoue, Yasushi
Kiryu, Junichi
author_facet Fujimoto, Hisataka
Ochi, Shintaro
Yamashita, Tsutomu
Inoue, Yasushi
Kiryu, Junichi
author_sort Fujimoto, Hisataka
collection PubMed
description PURPOSE: Soft contact lenses (SCLs) are effective for refractive error correction, but prolonged wear triggers discomfort and discontinuation. This study investigates whether water gradient technology of delefilcon A-based SCLs improve tear film dynamics. METHODS: This retrospective observational study included 50 asymptomatic delefilcon A or narafilcon A users. Data on thin aqueous layer break (TALB; %), noninvasive tear break-up time (NIBUT), tear meniscus height (TMH; mm), subjective dryness, and higher-order aberrations (HOAs) were collected. Measurements of the bare eye, the SCL-worn eye after 15 minutes (visit 1 [v1]) and 30 ± 5 days after v1 after SCL was worn for ≥5 hours (visit 2 [v2]) were recorded. RESULTS: TALB was significantly reduced in the delefilcon A group compared to the narafilcon A group (33.3% vs. 85.5% at v1; P < 0.0001 and 31.7% vs. 80.4% at v2; P < 0.0001). The NIBUT was also significantly higher in the former (4.2 ± 2.1 seconds vs. 2.9 ± 1.5 at v1; P < 0.01 and 4.1 ± 2.3 seconds vs. 2.7 ± 1.6 seconds at v2; P < 0.01) across both visits. The TMH was significantly reduced in the former in both v1 and v2. The total ocular HOAs were significantly lower in the former at v1 (P < 0.001) and v2 (P < 0.05) compared to the bare eye. CONCLUSIONS: The water gradient technology of delefilcon A reduces TALB and increases NIBUT. TRANSLATIONAL RELEVANCE: The use of water gradient technology improves tear film dynamics and alleviate pathological break-up pattern, improving lens performance.
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spelling pubmed-84198782021-09-22 Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens Fujimoto, Hisataka Ochi, Shintaro Yamashita, Tsutomu Inoue, Yasushi Kiryu, Junichi Transl Vis Sci Technol Article PURPOSE: Soft contact lenses (SCLs) are effective for refractive error correction, but prolonged wear triggers discomfort and discontinuation. This study investigates whether water gradient technology of delefilcon A-based SCLs improve tear film dynamics. METHODS: This retrospective observational study included 50 asymptomatic delefilcon A or narafilcon A users. Data on thin aqueous layer break (TALB; %), noninvasive tear break-up time (NIBUT), tear meniscus height (TMH; mm), subjective dryness, and higher-order aberrations (HOAs) were collected. Measurements of the bare eye, the SCL-worn eye after 15 minutes (visit 1 [v1]) and 30 ± 5 days after v1 after SCL was worn for ≥5 hours (visit 2 [v2]) were recorded. RESULTS: TALB was significantly reduced in the delefilcon A group compared to the narafilcon A group (33.3% vs. 85.5% at v1; P < 0.0001 and 31.7% vs. 80.4% at v2; P < 0.0001). The NIBUT was also significantly higher in the former (4.2 ± 2.1 seconds vs. 2.9 ± 1.5 at v1; P < 0.01 and 4.1 ± 2.3 seconds vs. 2.7 ± 1.6 seconds at v2; P < 0.01) across both visits. The TMH was significantly reduced in the former in both v1 and v2. The total ocular HOAs were significantly lower in the former at v1 (P < 0.001) and v2 (P < 0.05) compared to the bare eye. CONCLUSIONS: The water gradient technology of delefilcon A reduces TALB and increases NIBUT. TRANSLATIONAL RELEVANCE: The use of water gradient technology improves tear film dynamics and alleviate pathological break-up pattern, improving lens performance. The Association for Research in Vision and Ophthalmology 2021-09-02 /pmc/articles/PMC8419878/ /pubmed/34473222 http://dx.doi.org/10.1167/tvst.10.11.5 Text en Copyright 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Article
Fujimoto, Hisataka
Ochi, Shintaro
Yamashita, Tsutomu
Inoue, Yasushi
Kiryu, Junichi
Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens
title Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens
title_full Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens
title_fullStr Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens
title_full_unstemmed Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens
title_short Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens
title_sort role of the water gradient structure in inhibiting thin aqueous layer break in silicone hydrogel-soft contact lens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419878/
https://www.ncbi.nlm.nih.gov/pubmed/34473222
http://dx.doi.org/10.1167/tvst.10.11.5
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