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Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens
PURPOSE: Soft contact lenses (SCLs) are effective for refractive error correction, but prolonged wear triggers discomfort and discontinuation. This study investigates whether water gradient technology of delefilcon A-based SCLs improve tear film dynamics. METHODS: This retrospective observational st...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419878/ https://www.ncbi.nlm.nih.gov/pubmed/34473222 http://dx.doi.org/10.1167/tvst.10.11.5 |
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author | Fujimoto, Hisataka Ochi, Shintaro Yamashita, Tsutomu Inoue, Yasushi Kiryu, Junichi |
author_facet | Fujimoto, Hisataka Ochi, Shintaro Yamashita, Tsutomu Inoue, Yasushi Kiryu, Junichi |
author_sort | Fujimoto, Hisataka |
collection | PubMed |
description | PURPOSE: Soft contact lenses (SCLs) are effective for refractive error correction, but prolonged wear triggers discomfort and discontinuation. This study investigates whether water gradient technology of delefilcon A-based SCLs improve tear film dynamics. METHODS: This retrospective observational study included 50 asymptomatic delefilcon A or narafilcon A users. Data on thin aqueous layer break (TALB; %), noninvasive tear break-up time (NIBUT), tear meniscus height (TMH; mm), subjective dryness, and higher-order aberrations (HOAs) were collected. Measurements of the bare eye, the SCL-worn eye after 15 minutes (visit 1 [v1]) and 30 ± 5 days after v1 after SCL was worn for ≥5 hours (visit 2 [v2]) were recorded. RESULTS: TALB was significantly reduced in the delefilcon A group compared to the narafilcon A group (33.3% vs. 85.5% at v1; P < 0.0001 and 31.7% vs. 80.4% at v2; P < 0.0001). The NIBUT was also significantly higher in the former (4.2 ± 2.1 seconds vs. 2.9 ± 1.5 at v1; P < 0.01 and 4.1 ± 2.3 seconds vs. 2.7 ± 1.6 seconds at v2; P < 0.01) across both visits. The TMH was significantly reduced in the former in both v1 and v2. The total ocular HOAs were significantly lower in the former at v1 (P < 0.001) and v2 (P < 0.05) compared to the bare eye. CONCLUSIONS: The water gradient technology of delefilcon A reduces TALB and increases NIBUT. TRANSLATIONAL RELEVANCE: The use of water gradient technology improves tear film dynamics and alleviate pathological break-up pattern, improving lens performance. |
format | Online Article Text |
id | pubmed-8419878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-84198782021-09-22 Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens Fujimoto, Hisataka Ochi, Shintaro Yamashita, Tsutomu Inoue, Yasushi Kiryu, Junichi Transl Vis Sci Technol Article PURPOSE: Soft contact lenses (SCLs) are effective for refractive error correction, but prolonged wear triggers discomfort and discontinuation. This study investigates whether water gradient technology of delefilcon A-based SCLs improve tear film dynamics. METHODS: This retrospective observational study included 50 asymptomatic delefilcon A or narafilcon A users. Data on thin aqueous layer break (TALB; %), noninvasive tear break-up time (NIBUT), tear meniscus height (TMH; mm), subjective dryness, and higher-order aberrations (HOAs) were collected. Measurements of the bare eye, the SCL-worn eye after 15 minutes (visit 1 [v1]) and 30 ± 5 days after v1 after SCL was worn for ≥5 hours (visit 2 [v2]) were recorded. RESULTS: TALB was significantly reduced in the delefilcon A group compared to the narafilcon A group (33.3% vs. 85.5% at v1; P < 0.0001 and 31.7% vs. 80.4% at v2; P < 0.0001). The NIBUT was also significantly higher in the former (4.2 ± 2.1 seconds vs. 2.9 ± 1.5 at v1; P < 0.01 and 4.1 ± 2.3 seconds vs. 2.7 ± 1.6 seconds at v2; P < 0.01) across both visits. The TMH was significantly reduced in the former in both v1 and v2. The total ocular HOAs were significantly lower in the former at v1 (P < 0.001) and v2 (P < 0.05) compared to the bare eye. CONCLUSIONS: The water gradient technology of delefilcon A reduces TALB and increases NIBUT. TRANSLATIONAL RELEVANCE: The use of water gradient technology improves tear film dynamics and alleviate pathological break-up pattern, improving lens performance. The Association for Research in Vision and Ophthalmology 2021-09-02 /pmc/articles/PMC8419878/ /pubmed/34473222 http://dx.doi.org/10.1167/tvst.10.11.5 Text en Copyright 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Article Fujimoto, Hisataka Ochi, Shintaro Yamashita, Tsutomu Inoue, Yasushi Kiryu, Junichi Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens |
title | Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens |
title_full | Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens |
title_fullStr | Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens |
title_full_unstemmed | Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens |
title_short | Role of the Water Gradient Structure in Inhibiting Thin Aqueous Layer Break in Silicone Hydrogel-Soft Contact Lens |
title_sort | role of the water gradient structure in inhibiting thin aqueous layer break in silicone hydrogel-soft contact lens |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419878/ https://www.ncbi.nlm.nih.gov/pubmed/34473222 http://dx.doi.org/10.1167/tvst.10.11.5 |
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