Oncogene Concatenated Enriched Amplicon Nanopore Sequencing for rapid, accurate, and affordable somatic mutation detection

We develop the Oncogene Concatenated Enriched Amplicon Nanopore Sequencing (OCEANS) method, in which variants with low variant allele frequency (VAFs) are amplified and subsequently concatenated for Nanopore Sequencing. OCEANS allows accurate detection of somatic mutations with VAF limits of detecti...

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Detalles Bibliográficos
Autores principales: Thirunavukarasu, Deepak, Cheng, Lauren Y., Song, Ping, Chen, Sherry X., Borad, Mitesh J., Kwong, Lawrence, James, Phillip, Turner, Daniel J., Zhang, David Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419911/
https://www.ncbi.nlm.nih.gov/pubmed/34482832
http://dx.doi.org/10.1186/s13059-021-02449-1

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