The pan-PPAR agonist lanifibranor reduces development of lung fibrosis and attenuates cardiorespiratory manifestations in a transgenic mouse model of systemic sclerosis

BACKGROUND: The TβRII∆k-fib transgenic (TG) mouse model of scleroderma replicates key fibrotic and vasculopathic complications of systemic sclerosis through fibroblast-directed upregulation of TGFβ signalling. We have examined peroxisome proliferator-activated receptor (PPAR) pathway perturbation in...

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Detalles Bibliográficos
Autores principales: Derrett-Smith, Emma, Clark, Kristina E. N., Shiwen, Xu, Abraham, David J., Hoyles, Rachel K., Lacombe, Olivier, Broqua, Pierre, Junien, Jean Louis, Konstantinova, Irena, Ong, Voon H., Denton, Christopher P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419933/
https://www.ncbi.nlm.nih.gov/pubmed/34488870
http://dx.doi.org/10.1186/s13075-021-02592-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419933/
https://www.ncbi.nlm.nih.gov/pubmed/34488870
http://dx.doi.org/10.1186/s13075-021-02592-x

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