PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics

Polygenic risk scores (PRSs) have wide applications in human genetics research, but often include tuning parameters which are difficult to optimize in practice due to limited access to individual-level data. Here, we introduce PUMAS, a novel method to fine-tune PRS models using summary statistics fr...

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Detalles Bibliográficos
Autores principales: Zhao, Zijie, Yi, Yanyao, Song, Jie, Wu, Yuchang, Zhong, Xiaoyuan, Lin, Yupei, Hohman, Timothy J., Fletcher, Jason, Lu, Qiongshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419981/
https://www.ncbi.nlm.nih.gov/pubmed/34488838
http://dx.doi.org/10.1186/s13059-021-02479-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419981/
https://www.ncbi.nlm.nih.gov/pubmed/34488838
http://dx.doi.org/10.1186/s13059-021-02479-9

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