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PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics
Polygenic risk scores (PRSs) have wide applications in human genetics research, but often include tuning parameters which are difficult to optimize in practice due to limited access to individual-level data. Here, we introduce PUMAS, a novel method to fine-tune PRS models using summary statistics fr...
Autores principales: | Zhao, Zijie, Yi, Yanyao, Song, Jie, Wu, Yuchang, Zhong, Xiaoyuan, Lin, Yupei, Hohman, Timothy J., Fletcher, Jason, Lu, Qiongshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419981/ https://www.ncbi.nlm.nih.gov/pubmed/34488838 http://dx.doi.org/10.1186/s13059-021-02479-9 |
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