APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis

BACKGROUND: Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer’s disease (AD), as well as in young cognitively normal carriers of the Ε4 allele of Apolipoprotein E (APOE), the strongest genetic predictor of late-onset AD. While this clinical feature has been descr...

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Detalles Bibliográficos
Autores principales: Farmer, Brandon C., Williams, Holden C., Devanney, Nicholas A., Piron, Margaret A., Nation, Grant K., Carter, David J., Walsh, Adeline E., Khanal, Rebika, Young, Lyndsay E. A., Kluemper, Jude C., Hernandez, Gabriela, Allenger, Elizabeth J., Mooney, Rachel, Golden, Lesley R., Smith, Cathryn T., Brandon, J. Anthony, Gupta, Vedant A., Kern, Philip A., Gentry, Matthew S., Morganti, Josh M., Sun, Ramon C., Johnson, Lance A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420022/
https://www.ncbi.nlm.nih.gov/pubmed/34488832
http://dx.doi.org/10.1186/s13024-021-00483-y

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