Profiling diverse sequence tandem repeats in colorectal cancer reveals co-occurrence of microsatellite and chromosomal instability involving Chromosome 8

We developed a sensitive sequencing approach that simultaneously profiles microsatellite instability, chromosomal instability, and subclonal structure in cancer. We assessed diverse repeat motifs across 225 microsatellites on colorectal carcinomas. Our study identified elevated alterations at both s...

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Detalles Bibliográficos
Autores principales: Shin, GiWon, Greer, Stephanie U., Hopmans, Erik, Grimes, Susan M., Lee, HoJoon, Zhao, Lan, Miotke, Laura, Suarez, Carlos, Almeda, Alison F., Haraldsdottir, Sigurdis, Ji, Hanlee P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420050/
https://www.ncbi.nlm.nih.gov/pubmed/34488871
http://dx.doi.org/10.1186/s13073-021-00958-z

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