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Fasting plasma glucose and glucose fluctuation are associated with COVID-19 prognosis regardless of pre-existing diabetes
AIMS: We aimed to investigate the role of Fasting Plasma Glucose (FPG) and glucose fluctuation in the prognosis of COVID-19 patients stratified by pre-existing diabetes. METHODS: The associations of FPG and glucose fluctuation indexes with prognosis of COVID-19 in 2,642 patients were investigated by...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420085/ https://www.ncbi.nlm.nih.gov/pubmed/34500004 http://dx.doi.org/10.1016/j.diabres.2021.109041 |
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author | Xie, Weijia Wu, Na Wang, Bin Xu, Yu Zhang, Yao Xiang, Ying Zhang, Wenjing Chen, Zheng Yuan, Zhiquan Li, Chengying Jia, Xiaoyue Shan, Yifan Xu, Bin Bai, Li Zhong, Li Li, Yafei |
author_facet | Xie, Weijia Wu, Na Wang, Bin Xu, Yu Zhang, Yao Xiang, Ying Zhang, Wenjing Chen, Zheng Yuan, Zhiquan Li, Chengying Jia, Xiaoyue Shan, Yifan Xu, Bin Bai, Li Zhong, Li Li, Yafei |
author_sort | Xie, Weijia |
collection | PubMed |
description | AIMS: We aimed to investigate the role of Fasting Plasma Glucose (FPG) and glucose fluctuation in the prognosis of COVID-19 patients stratified by pre-existing diabetes. METHODS: The associations of FPG and glucose fluctuation indexes with prognosis of COVID-19 in 2,642 patients were investigated by multivariate Cox regression analysis. The primary outcome was in-hospital mortality; the secondary outcome was disease progression. The longitudinal changes of FPG over time were analyzed by the latent growth curve model in COVID-19 patients stratified by diabetes and severity of COVID-19. RESULTS: We found FPG as an independent prognostic factor of overall survival after adjustment for age, sex, diabetes and severity of COVID-19 at admission (HR: 1.15, 95% CI: 1.06–1.25, P = 1.02 × 10(−3)). Multivariate logistic regression analysis indicated that the standard deviation of blood glucose (SDBG) and largest amplitude of glycemic excursions (LAGE) were also independent risk factors of COVID-19 progression (P = 0.03 and 0.04, respectively). The growth trajectory of FPG over the first 3 days of hospitalization was steeper in patients with critical COVID-19 in comparison to moderate patients. CONCLUSIONS: Hyperglycemia and glucose fluctuation were adverse prognostic factors of COVID-19 regardless of pre-existing diabetes. This stresses the importance of glycemic control in addition to other therapeutic management. |
format | Online Article Text |
id | pubmed-8420085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84200852021-09-07 Fasting plasma glucose and glucose fluctuation are associated with COVID-19 prognosis regardless of pre-existing diabetes Xie, Weijia Wu, Na Wang, Bin Xu, Yu Zhang, Yao Xiang, Ying Zhang, Wenjing Chen, Zheng Yuan, Zhiquan Li, Chengying Jia, Xiaoyue Shan, Yifan Xu, Bin Bai, Li Zhong, Li Li, Yafei Diabetes Res Clin Pract Article AIMS: We aimed to investigate the role of Fasting Plasma Glucose (FPG) and glucose fluctuation in the prognosis of COVID-19 patients stratified by pre-existing diabetes. METHODS: The associations of FPG and glucose fluctuation indexes with prognosis of COVID-19 in 2,642 patients were investigated by multivariate Cox regression analysis. The primary outcome was in-hospital mortality; the secondary outcome was disease progression. The longitudinal changes of FPG over time were analyzed by the latent growth curve model in COVID-19 patients stratified by diabetes and severity of COVID-19. RESULTS: We found FPG as an independent prognostic factor of overall survival after adjustment for age, sex, diabetes and severity of COVID-19 at admission (HR: 1.15, 95% CI: 1.06–1.25, P = 1.02 × 10(−3)). Multivariate logistic regression analysis indicated that the standard deviation of blood glucose (SDBG) and largest amplitude of glycemic excursions (LAGE) were also independent risk factors of COVID-19 progression (P = 0.03 and 0.04, respectively). The growth trajectory of FPG over the first 3 days of hospitalization was steeper in patients with critical COVID-19 in comparison to moderate patients. CONCLUSIONS: Hyperglycemia and glucose fluctuation were adverse prognostic factors of COVID-19 regardless of pre-existing diabetes. This stresses the importance of glycemic control in addition to other therapeutic management. Elsevier B.V. 2021-10 2021-09-06 /pmc/articles/PMC8420085/ /pubmed/34500004 http://dx.doi.org/10.1016/j.diabres.2021.109041 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Xie, Weijia Wu, Na Wang, Bin Xu, Yu Zhang, Yao Xiang, Ying Zhang, Wenjing Chen, Zheng Yuan, Zhiquan Li, Chengying Jia, Xiaoyue Shan, Yifan Xu, Bin Bai, Li Zhong, Li Li, Yafei Fasting plasma glucose and glucose fluctuation are associated with COVID-19 prognosis regardless of pre-existing diabetes |
title | Fasting plasma glucose and glucose fluctuation are associated with COVID-19 prognosis regardless of pre-existing diabetes |
title_full | Fasting plasma glucose and glucose fluctuation are associated with COVID-19 prognosis regardless of pre-existing diabetes |
title_fullStr | Fasting plasma glucose and glucose fluctuation are associated with COVID-19 prognosis regardless of pre-existing diabetes |
title_full_unstemmed | Fasting plasma glucose and glucose fluctuation are associated with COVID-19 prognosis regardless of pre-existing diabetes |
title_short | Fasting plasma glucose and glucose fluctuation are associated with COVID-19 prognosis regardless of pre-existing diabetes |
title_sort | fasting plasma glucose and glucose fluctuation are associated with covid-19 prognosis regardless of pre-existing diabetes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420085/ https://www.ncbi.nlm.nih.gov/pubmed/34500004 http://dx.doi.org/10.1016/j.diabres.2021.109041 |
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