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Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report

BACKGROUND: Since introducing the SARS-CoV-2 vaccination, different adverse effects and complications have been linked to the vaccine. Variable neurological complications have been reported after receiving the COVID-19 vaccine, such as acute encephalopathy. CASE PRESENTATION: In this report, we desc...

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Autores principales: Al-Mashdali, Abdulrahman F., Ata, Yaser M., Sadik, Nagham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420261/
https://www.ncbi.nlm.nih.gov/pubmed/34512961
http://dx.doi.org/10.1016/j.amsu.2021.102803
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author Al-Mashdali, Abdulrahman F.
Ata, Yaser M.
Sadik, Nagham
author_facet Al-Mashdali, Abdulrahman F.
Ata, Yaser M.
Sadik, Nagham
author_sort Al-Mashdali, Abdulrahman F.
collection PubMed
description BACKGROUND: Since introducing the SARS-CoV-2 vaccination, different adverse effects and complications have been linked to the vaccine. Variable neurological complications have been reported after receiving the COVID-19 vaccine, such as acute encephalopathy. CASE PRESENTATION: In this report, we describe a 32-year-old previously healthy man who developed acute confusion, memory disturbances, and auditory hallucination within 24 hours from getting his first dose of the COVID-19 Moderna vaccine.EEG showed features of encephalopathy, CSF investigations were nonspecific, and MRI head did not depict any abnormality. He received five days of ceftriaxone and acyclovir without any benefit. DISCUSSION: Extensive workup for different causes of acute encephalopathy, including autoimmune encephalitis, was negative. Also, Our patient improved dramatically after receiving methylprednisolone, supporting an immune-mediated mechanism behind his acute presentation. Accordingly, we think the COVID-19 vaccine is the only possible cause of our patient presentation, giving the temporal relationship and the absence of other risk factors for encephalopathy. CONCLUSION: the clinician should be aware of the possible neurological complications of the different COVID-19 vaccines. Further research is needed to clarify the pathophysiology of such complications.
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spelling pubmed-84202612021-09-07 Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report Al-Mashdali, Abdulrahman F. Ata, Yaser M. Sadik, Nagham Ann Med Surg (Lond) Case Report BACKGROUND: Since introducing the SARS-CoV-2 vaccination, different adverse effects and complications have been linked to the vaccine. Variable neurological complications have been reported after receiving the COVID-19 vaccine, such as acute encephalopathy. CASE PRESENTATION: In this report, we describe a 32-year-old previously healthy man who developed acute confusion, memory disturbances, and auditory hallucination within 24 hours from getting his first dose of the COVID-19 Moderna vaccine.EEG showed features of encephalopathy, CSF investigations were nonspecific, and MRI head did not depict any abnormality. He received five days of ceftriaxone and acyclovir without any benefit. DISCUSSION: Extensive workup for different causes of acute encephalopathy, including autoimmune encephalitis, was negative. Also, Our patient improved dramatically after receiving methylprednisolone, supporting an immune-mediated mechanism behind his acute presentation. Accordingly, we think the COVID-19 vaccine is the only possible cause of our patient presentation, giving the temporal relationship and the absence of other risk factors for encephalopathy. CONCLUSION: the clinician should be aware of the possible neurological complications of the different COVID-19 vaccines. Further research is needed to clarify the pathophysiology of such complications. Elsevier 2021-09-06 /pmc/articles/PMC8420261/ /pubmed/34512961 http://dx.doi.org/10.1016/j.amsu.2021.102803 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Al-Mashdali, Abdulrahman F.
Ata, Yaser M.
Sadik, Nagham
Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report
title Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report
title_full Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report
title_fullStr Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report
title_full_unstemmed Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report
title_short Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report
title_sort post-covid-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420261/
https://www.ncbi.nlm.nih.gov/pubmed/34512961
http://dx.doi.org/10.1016/j.amsu.2021.102803
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