A pair of noncompeting neutralizing human monoclonal antibodies protecting from disease in a SARS‐CoV‐2 infection model

TRIANNI mice carry an entire set of human immunoglobulin V region gene segments and are a powerful tool to rapidly isolate human monoclonal antibodies. After immunizing these mice with DNA encoding the spike protein of SARS‐CoV‐2 and boosting with spike protein, we identified 29 hybridoma antibodies...

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Detalles Bibliográficos
Autores principales: Peter, Antonia Sophia, Roth, Edith, Schulz, Sebastian R., Fraedrich, Kirsten, Steinmetz, Tobit, Damm, Dominik, Hauke, Manuela, Richel, Elie, Mueller‐Schmucker, Sandra, Habenicht, Katharina, Eberlein, Valentina, Issmail, Leila, Uhlig, Nadja, Dolles, Simon, Grüner, Eva, Peterhoff, David, Ciesek, Sandra, Hoffmann, Markus, Pöhlmann, Stefan, McKay, Paul F., Shattock, Robin J., Wölfel, Roman, Socher, Eileen, Wagner, Ralf, Eichler, Jutta, Sticht, Heinrich, Schuh, Wolfgang, Neipel, Frank, Ensser, Armin, Mielenz, Dirk, Tenbusch, Matthias, Winkler, Thomas H., Grunwald, Thomas, Überla, Klaus, Jäck, Hans‐Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Immunity to infection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420377/
https://www.ncbi.nlm.nih.gov/pubmed/34355795
http://dx.doi.org/10.1002/eji.202149374

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