Application of quantitative systems pharmacology to guide the optimal dosing of COVID‐19 vaccines

Optimal use and distribution of coronavirus disease 2019 (COVID‐19) vaccines involves adjustments of dosing. Due to the rapidly evolving pandemic, such adjustments often need to be introduced before full efficacy data are available. As demonstrated in other areas of drug development, quantitative sy...

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Detalles Bibliográficos
Autores principales: Giorgi, Mario, Desikan, Rajat, van der Graaf, Piet H., Kierzek, Andrzej M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420530/
https://www.ncbi.nlm.nih.gov/pubmed/34331834
http://dx.doi.org/10.1002/psp4.12700
Descripción
Sumario:Optimal use and distribution of coronavirus disease 2019 (COVID‐19) vaccines involves adjustments of dosing. Due to the rapidly evolving pandemic, such adjustments often need to be introduced before full efficacy data are available. As demonstrated in other areas of drug development, quantitative systems pharmacology (QSP) is well placed to guide such extrapolation in a rational and timely manner. Here, we propose for the first time how QSP can be applied in the context of COVID‐19 vaccine development.

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