Specific detection of memory T‐cells in COVID‐19 patients using standardized whole‐blood Interferon gammarelease assay

Antigen‐specific T‐cells are essential for protective immunity against SARS‐CoV‐2. We set up a semi‐automated whole‐blood Interferon‐gamma release assay (WB IGRA) to monitor the T‐cell response after stimulation with SARS‐CoV‐2 peptide pools. We report that the WB IGRA is complementary to serologica...

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Detalles Bibliográficos
Autores principales: Mouton, William, Compagnon, Christelle, Saker, Kahina, Daniel, Soizic, Djebali, Sophia, Lacoux, Xavier, Pozzetto, Bruno, Oriol, Guy, Laubreton, Daphné, Prieux, Margaux, Fassier, Jean‐Baptiste, Guibert, Nicolas, Massardier‐Pilonchéry, Amélie, Alfaiate, Dulce, Berthier, Franck, Walzer, Thierry, Marvel, Jacqueline, Brengel‐Pesce, Karen, Trouiller‐Assant, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Letters to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420580/
https://www.ncbi.nlm.nih.gov/pubmed/34387859
http://dx.doi.org/10.1002/eji.202149296
Descripción
Sumario:Antigen‐specific T‐cells are essential for protective immunity against SARS‐CoV‐2. We set up a semi‐automated whole‐blood Interferon‐gamma release assay (WB IGRA) to monitor the T‐cell response after stimulation with SARS‐CoV‐2 peptide pools. We report that the WB IGRA is complementary to serological assays to assess SARS‐CoV‐2 immunity. [Image: see text]

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