Intratumoral injection of TLR9 agonist promotes an immunopermissive microenvironment transition and causes cooperative antitumor activity in combination with anti-PD1 in pancreatic cancer

BACKGROUND: Complex tumor and immune microenvironment render pancreatic ductal adenocarcinoma (PDAC) resistant to immune checkpoint inhibitors (ICIs). Therefore, a strategy to convert the immune hostile into an immunopermissive tumor is required. Recent studies showed that intratumoral injection of...

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Detalles Bibliográficos
Autores principales: Carbone, Carmine, Piro, Geny, Agostini, Antonio, Delfino, Pietro, De Sanctis, Francesco, Nasca, Vincenzo, Spallotta, Francesco, Sette, Claudio, Martini, Maurizio, Ugel, Stefano, Corbo, Vincenzo, Cappello, Paola, Bria, Emilio, Scarpa, Aldo, Tortora, Giampaolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420705/
https://www.ncbi.nlm.nih.gov/pubmed/34479922
http://dx.doi.org/10.1136/jitc-2021-002876

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