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Conformational flexibility of EptA driven by an interdomain helix provides insights for enzyme–substrate recognition

Many pathogenic gram-negative bacteria have developed mechanisms to increase resistance to cationic antimicrobial peptides by modifying the lipid A moiety. One modification is the addition of phosphoethanolamine to lipid A by the enzyme phosphoethanolamine transferase (EptA). Previously we repor...

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Detalles Bibliográficos
Autores principales:	Anandan, Anandhi, Dunstan, Nicholas W., Ryan, Timothy M., Mertens, Haydyn D. T., Lim, Katherine Y. L., Evans, Genevieve L., Kahler, Charlene M., Vrielink, Alice
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2021
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420757/ https://www.ncbi.nlm.nih.gov/pubmed/34584735 http://dx.doi.org/10.1107/S2052252521005613

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