Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes

Pancreatic β-cell failure is the key pathogenic element of the complex metabolic deterioration in type 2 diabetes (T2D); its underlying pathomechanism is still elusive. Here, we identify pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 (PHLPP1/2) as phosphatases whose upre...

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Detalles Bibliográficos
Autores principales: Lupse, Blaz, Annamalai, Karthika, Ibrahim, Hazem, Kaur, Supreet, Geravandi, Shirin, Sarma, Bhavishya, Pal, Anasua, Awal, Sushil, Joshi, Arundhati, Rafizadeh, Sahar, Madduri, Murali Krishna, Khazaei, Mona, Liu, Huan, Yuan, Ting, He, Wei, Gorrepati, Kanaka Durga Devi, Azizi, Zahra, Qi, Qi, Ye, Keqiang, Oberholzer, Jose, Maedler, Kathrin, Ardestani, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421018/
https://www.ncbi.nlm.nih.gov/pubmed/34348155
http://dx.doi.org/10.1016/j.celrep.2021.109490

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