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SARS-CoV-2 wastewater surveillance data can predict hospitalizations and ICU admissions

We measured SARS-CoV-2 RNA load in raw wastewater in Attica, Greece, by RT-qPCR for the environmental surveillance of COVID-19 for 6 months. The lag between RNA load and pandemic indicators (COVID-19 hospital and intensive care unit (ICU) admissions) was calculated using a grid search. Our results s...

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Autores principales: Galani, Aikaterini, Aalizadeh, Reza, Kostakis, Marios, Markou, Athina, Alygizakis, Nikiforos, Lytras, Theodore, Adamopoulos, Panagiotis G., Peccia, Jordan, Thompson, David C., Kontou, Aikaterini, Karagiannidis, Apostolos, Lianidou, Evi S., Avgeris, Margaritis, Paraskevis, Dimitrios, Tsiodras, Sotirios, Scorilas, Andreas, Vasiliou, Vasilis, Dimopoulos, Meletios-Athanasios, Thomaidis, Nikolaos S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421077/
https://www.ncbi.nlm.nih.gov/pubmed/34623953
http://dx.doi.org/10.1016/j.scitotenv.2021.150151
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author Galani, Aikaterini
Aalizadeh, Reza
Kostakis, Marios
Markou, Athina
Alygizakis, Nikiforos
Lytras, Theodore
Adamopoulos, Panagiotis G.
Peccia, Jordan
Thompson, David C.
Kontou, Aikaterini
Karagiannidis, Apostolos
Lianidou, Evi S.
Avgeris, Margaritis
Paraskevis, Dimitrios
Tsiodras, Sotirios
Scorilas, Andreas
Vasiliou, Vasilis
Dimopoulos, Meletios-Athanasios
Thomaidis, Nikolaos S.
author_facet Galani, Aikaterini
Aalizadeh, Reza
Kostakis, Marios
Markou, Athina
Alygizakis, Nikiforos
Lytras, Theodore
Adamopoulos, Panagiotis G.
Peccia, Jordan
Thompson, David C.
Kontou, Aikaterini
Karagiannidis, Apostolos
Lianidou, Evi S.
Avgeris, Margaritis
Paraskevis, Dimitrios
Tsiodras, Sotirios
Scorilas, Andreas
Vasiliou, Vasilis
Dimopoulos, Meletios-Athanasios
Thomaidis, Nikolaos S.
author_sort Galani, Aikaterini
collection PubMed
description We measured SARS-CoV-2 RNA load in raw wastewater in Attica, Greece, by RT-qPCR for the environmental surveillance of COVID-19 for 6 months. The lag between RNA load and pandemic indicators (COVID-19 hospital and intensive care unit (ICU) admissions) was calculated using a grid search. Our results showed that RNA load in raw wastewater is a leading indicator of positive COVID-19 cases, new hospitalization and admission into ICUs by 5, 8 and 9 days, respectively. Modelling techniques based on distributed/fixed lag modelling, linear regression and artificial neural networks were utilized to build relationships between SARS-CoV-2 RNA load in wastewater and pandemic health indicators. SARS-CoV-2 mutation analysis in wastewater during the third pandemic wave revealed that the alpha-variant was dominant. Our results demonstrate that clinical and environmental surveillance data can be combined to create robust models to study the on-going COVID-19 infection dynamics and provide an early warning for increased hospital admissions.
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spelling pubmed-84210772021-09-07 SARS-CoV-2 wastewater surveillance data can predict hospitalizations and ICU admissions Galani, Aikaterini Aalizadeh, Reza Kostakis, Marios Markou, Athina Alygizakis, Nikiforos Lytras, Theodore Adamopoulos, Panagiotis G. Peccia, Jordan Thompson, David C. Kontou, Aikaterini Karagiannidis, Apostolos Lianidou, Evi S. Avgeris, Margaritis Paraskevis, Dimitrios Tsiodras, Sotirios Scorilas, Andreas Vasiliou, Vasilis Dimopoulos, Meletios-Athanasios Thomaidis, Nikolaos S. Sci Total Environ Article We measured SARS-CoV-2 RNA load in raw wastewater in Attica, Greece, by RT-qPCR for the environmental surveillance of COVID-19 for 6 months. The lag between RNA load and pandemic indicators (COVID-19 hospital and intensive care unit (ICU) admissions) was calculated using a grid search. Our results showed that RNA load in raw wastewater is a leading indicator of positive COVID-19 cases, new hospitalization and admission into ICUs by 5, 8 and 9 days, respectively. Modelling techniques based on distributed/fixed lag modelling, linear regression and artificial neural networks were utilized to build relationships between SARS-CoV-2 RNA load in wastewater and pandemic health indicators. SARS-CoV-2 mutation analysis in wastewater during the third pandemic wave revealed that the alpha-variant was dominant. Our results demonstrate that clinical and environmental surveillance data can be combined to create robust models to study the on-going COVID-19 infection dynamics and provide an early warning for increased hospital admissions. Elsevier B.V. 2022-01-15 2021-09-07 /pmc/articles/PMC8421077/ /pubmed/34623953 http://dx.doi.org/10.1016/j.scitotenv.2021.150151 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Galani, Aikaterini
Aalizadeh, Reza
Kostakis, Marios
Markou, Athina
Alygizakis, Nikiforos
Lytras, Theodore
Adamopoulos, Panagiotis G.
Peccia, Jordan
Thompson, David C.
Kontou, Aikaterini
Karagiannidis, Apostolos
Lianidou, Evi S.
Avgeris, Margaritis
Paraskevis, Dimitrios
Tsiodras, Sotirios
Scorilas, Andreas
Vasiliou, Vasilis
Dimopoulos, Meletios-Athanasios
Thomaidis, Nikolaos S.
SARS-CoV-2 wastewater surveillance data can predict hospitalizations and ICU admissions
title SARS-CoV-2 wastewater surveillance data can predict hospitalizations and ICU admissions
title_full SARS-CoV-2 wastewater surveillance data can predict hospitalizations and ICU admissions
title_fullStr SARS-CoV-2 wastewater surveillance data can predict hospitalizations and ICU admissions
title_full_unstemmed SARS-CoV-2 wastewater surveillance data can predict hospitalizations and ICU admissions
title_short SARS-CoV-2 wastewater surveillance data can predict hospitalizations and ICU admissions
title_sort sars-cov-2 wastewater surveillance data can predict hospitalizations and icu admissions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421077/
https://www.ncbi.nlm.nih.gov/pubmed/34623953
http://dx.doi.org/10.1016/j.scitotenv.2021.150151
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