Two distinct pathways of RNA polymerase backtracking determine the requirement for the Trigger Loop during RNA hydrolysis

Transcribing RNA polymerase (RNAP) can fall into backtracking, phenomenon when the 3′ end of the transcript disengages from the template DNA. Backtracking is caused by sequences of the nucleic acids or by misincorporation of erroneous nucleotides. To resume productive elongation backtracked complexe...

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Detalles Bibliográficos
Autores principales: Mosaei, Hamed, Zenkin, Nikolay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421135/
https://www.ncbi.nlm.nih.gov/pubmed/34365509
http://dx.doi.org/10.1093/nar/gkab675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421135/
https://www.ncbi.nlm.nih.gov/pubmed/34365509
http://dx.doi.org/10.1093/nar/gkab675

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