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Two distinct pathways of RNA polymerase backtracking determine the requirement for the Trigger Loop during RNA hydrolysis
Transcribing RNA polymerase (RNAP) can fall into backtracking, phenomenon when the 3′ end of the transcript disengages from the template DNA. Backtracking is caused by sequences of the nucleic acids or by misincorporation of erroneous nucleotides. To resume productive elongation backtracked complexe...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421135/ https://www.ncbi.nlm.nih.gov/pubmed/34365509 http://dx.doi.org/10.1093/nar/gkab675 |