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A novel mechanism of enhanced transcription activity and fidelity for influenza A viral RNA-dependent RNA polymerase

During RNA elongation, the influenza A viral (IAV) RNA-dependent RNA polymerase (RdRp) residues in the active site interact with the triphosphate moiety of nucleoside triphosphate (NTP) for catalysis. The molecular mechanisms by which they control the rate and fidelity of NTP incorporation remain el...

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Detalles Bibliográficos
Autores principales:	Xu, Xinzhou, Zhang, Lu, Chu, Julie Tung Sem, Wang, Yuqing, Chin, Alex Wing Hong, Chong, Tin Hang, Dai, Zixi, Poon, Leo Lit Man, Cheung, Peter Pak-Hang, Huang, Xuhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421151/ https://www.ncbi.nlm.nih.gov/pubmed/34379778 http://dx.doi.org/10.1093/nar/gkab660

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