Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma

Sporadic reports of factitious elevations of thyroid hormones related to laboratory interference from autoantibodies and multiple myeloma paraproteins have appeared in the literature. Such clinically confusing laboratory results can lead to erroneous diagnoses and inappropriate treatments. We report...

Descripción completa

Detalles Bibliográficos
Autores principales: Mandal, Kaushik, Ashorobi, Damilola, Lee, Alice, Liao, Huijuan, Kumar, Salini C., Rosenthal, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421174/
https://www.ncbi.nlm.nih.gov/pubmed/34497729
http://dx.doi.org/10.1155/2021/8479193
_version_ 1783749022595416064
author Mandal, Kaushik
Ashorobi, Damilola
Lee, Alice
Liao, Huijuan
Kumar, Salini C.
Rosenthal, David S.
author_facet Mandal, Kaushik
Ashorobi, Damilola
Lee, Alice
Liao, Huijuan
Kumar, Salini C.
Rosenthal, David S.
author_sort Mandal, Kaushik
collection PubMed
description Sporadic reports of factitious elevations of thyroid hormones related to laboratory interference from autoantibodies and multiple myeloma paraproteins have appeared in the literature. Such clinically confusing laboratory results can lead to erroneous diagnoses and inappropriate treatments. We report an additional case of a patient with multiple myeloma and an IgG paraproteinemia who had such a spurious elevation of total T3 complicating her levothyroxine management of hypothyroidism. In addition, we alert clinicians that differences in performance characteristics between various manufacturers' test platforms may also cause spurious reports.
format Online
Article
Text
id pubmed-8421174
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-84211742021-09-07 Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma Mandal, Kaushik Ashorobi, Damilola Lee, Alice Liao, Huijuan Kumar, Salini C. Rosenthal, David S. Case Rep Endocrinol Case Report Sporadic reports of factitious elevations of thyroid hormones related to laboratory interference from autoantibodies and multiple myeloma paraproteins have appeared in the literature. Such clinically confusing laboratory results can lead to erroneous diagnoses and inappropriate treatments. We report an additional case of a patient with multiple myeloma and an IgG paraproteinemia who had such a spurious elevation of total T3 complicating her levothyroxine management of hypothyroidism. In addition, we alert clinicians that differences in performance characteristics between various manufacturers' test platforms may also cause spurious reports. Hindawi 2021-08-30 /pmc/articles/PMC8421174/ /pubmed/34497729 http://dx.doi.org/10.1155/2021/8479193 Text en Copyright © 2021 Kaushik Mandal et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Mandal, Kaushik
Ashorobi, Damilola
Lee, Alice
Liao, Huijuan
Kumar, Salini C.
Rosenthal, David S.
Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma
title Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma
title_full Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma
title_fullStr Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma
title_full_unstemmed Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma
title_short Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma
title_sort factitiously elevated total triiodothyronine in a euthyroid patient with multiple myeloma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421174/
https://www.ncbi.nlm.nih.gov/pubmed/34497729
http://dx.doi.org/10.1155/2021/8479193
work_keys_str_mv AT mandalkaushik factitiouslyelevatedtotaltriiodothyronineinaeuthyroidpatientwithmultiplemyeloma
AT ashorobidamilola factitiouslyelevatedtotaltriiodothyronineinaeuthyroidpatientwithmultiplemyeloma
AT leealice factitiouslyelevatedtotaltriiodothyronineinaeuthyroidpatientwithmultiplemyeloma
AT liaohuijuan factitiouslyelevatedtotaltriiodothyronineinaeuthyroidpatientwithmultiplemyeloma
AT kumarsalinic factitiouslyelevatedtotaltriiodothyronineinaeuthyroidpatientwithmultiplemyeloma
AT rosenthaldavids factitiouslyelevatedtotaltriiodothyronineinaeuthyroidpatientwithmultiplemyeloma

Ejemplares similares