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Grand scale genome manipulation via chromosome swapping in Escherichia coli programmed by three one megabase chromosomes
In bacterial synthetic biology, whole genome transplantation has been achieved only in mycoplasmas that contain a small genome and are competent for foreign genome uptake. In this study, we developed Escherichia coli strains programmed by three 1-megabase (Mb) chromosomes by splitting the 3-Mb chrom...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421210/ https://www.ncbi.nlm.nih.gov/pubmed/33907814 http://dx.doi.org/10.1093/nar/gkab298 |