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Gut Microbiota–Informed Precision Nutrition in the Generally Healthy Individual: Are We There Yet?
Since next generation sequencing facilitated high-throughput and cost-efficient genomics analyses, the human gut metagenome has become an emerging frontier to explore toward precision nutrition. Significant progress has been made in identifying gut microbial features associated with a wide spectrum...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421235/ https://www.ncbi.nlm.nih.gov/pubmed/34514287 http://dx.doi.org/10.1093/cdn/nzab107 |
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author | Nogal, Bartek Blumberg, Jeffrey B Blander, Gil Jorge, Milena |
author_facet | Nogal, Bartek Blumberg, Jeffrey B Blander, Gil Jorge, Milena |
author_sort | Nogal, Bartek |
collection | PubMed |
description | Since next generation sequencing facilitated high-throughput and cost-efficient genomics analyses, the human gut metagenome has become an emerging frontier to explore toward precision nutrition. Significant progress has been made in identifying gut microbial features associated with a wide spectrum of human disease. However, other than a few microbiome-disease relations, there is a dearth of confirmed causal inferences, particularly in generally healthy populations. The relatively high unexplained variability in microbiome compositions in this group warrants caution in applying this complex biomarker toward precision nutrition, because our understanding of what constitutes a healthy microbiome is still rudimentary. Although gut microbiota harbor integrated environmental and host-specific information with the potential to facilitate personalized nutritional and lifestyle advice, these data cannot yet be confidently interpreted toward precise recommendations. Thus, nutritional advice for generally healthy individuals based on personal microbiome composition analysis might not yet be appropriate unless accompanied by established blood and physiological biomarkers. |
format | Online Article Text |
id | pubmed-8421235 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-84212352021-09-09 Gut Microbiota–Informed Precision Nutrition in the Generally Healthy Individual: Are We There Yet? Nogal, Bartek Blumberg, Jeffrey B Blander, Gil Jorge, Milena Curr Dev Nutr PERSPECTIVES AND OPINIONS Since next generation sequencing facilitated high-throughput and cost-efficient genomics analyses, the human gut metagenome has become an emerging frontier to explore toward precision nutrition. Significant progress has been made in identifying gut microbial features associated with a wide spectrum of human disease. However, other than a few microbiome-disease relations, there is a dearth of confirmed causal inferences, particularly in generally healthy populations. The relatively high unexplained variability in microbiome compositions in this group warrants caution in applying this complex biomarker toward precision nutrition, because our understanding of what constitutes a healthy microbiome is still rudimentary. Although gut microbiota harbor integrated environmental and host-specific information with the potential to facilitate personalized nutritional and lifestyle advice, these data cannot yet be confidently interpreted toward precise recommendations. Thus, nutritional advice for generally healthy individuals based on personal microbiome composition analysis might not yet be appropriate unless accompanied by established blood and physiological biomarkers. Oxford University Press 2021-08-09 /pmc/articles/PMC8421235/ /pubmed/34514287 http://dx.doi.org/10.1093/cdn/nzab107 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | PERSPECTIVES AND OPINIONS Nogal, Bartek Blumberg, Jeffrey B Blander, Gil Jorge, Milena Gut Microbiota–Informed Precision Nutrition in the Generally Healthy Individual: Are We There Yet? |
title | Gut Microbiota–Informed Precision Nutrition in the Generally Healthy Individual: Are We There Yet? |
title_full | Gut Microbiota–Informed Precision Nutrition in the Generally Healthy Individual: Are We There Yet? |
title_fullStr | Gut Microbiota–Informed Precision Nutrition in the Generally Healthy Individual: Are We There Yet? |
title_full_unstemmed | Gut Microbiota–Informed Precision Nutrition in the Generally Healthy Individual: Are We There Yet? |
title_short | Gut Microbiota–Informed Precision Nutrition in the Generally Healthy Individual: Are We There Yet? |
title_sort | gut microbiota–informed precision nutrition in the generally healthy individual: are we there yet? |
topic | PERSPECTIVES AND OPINIONS |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421235/ https://www.ncbi.nlm.nih.gov/pubmed/34514287 http://dx.doi.org/10.1093/cdn/nzab107 |
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