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Gut Microbiota–Informed Precision Nutrition in the Generally Healthy Individual: Are We There Yet?

Since next generation sequencing facilitated high-throughput and cost-efficient genomics analyses, the human gut metagenome has become an emerging frontier to explore toward precision nutrition. Significant progress has been made in identifying gut microbial features associated with a wide spectrum...

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Detalles Bibliográficos
Autores principales: Nogal, Bartek, Blumberg, Jeffrey B, Blander, Gil, Jorge, Milena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421235/
https://www.ncbi.nlm.nih.gov/pubmed/34514287
http://dx.doi.org/10.1093/cdn/nzab107
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author Nogal, Bartek
Blumberg, Jeffrey B
Blander, Gil
Jorge, Milena
author_facet Nogal, Bartek
Blumberg, Jeffrey B
Blander, Gil
Jorge, Milena
author_sort Nogal, Bartek
collection PubMed
description Since next generation sequencing facilitated high-throughput and cost-efficient genomics analyses, the human gut metagenome has become an emerging frontier to explore toward precision nutrition. Significant progress has been made in identifying gut microbial features associated with a wide spectrum of human disease. However, other than a few microbiome-disease relations, there is a dearth of confirmed causal inferences, particularly in generally healthy populations. The relatively high unexplained variability in microbiome compositions in this group warrants caution in applying this complex biomarker toward precision nutrition, because our understanding of what constitutes a healthy microbiome is still rudimentary. Although gut microbiota harbor integrated environmental and host-specific information with the potential to facilitate personalized nutritional and lifestyle advice, these data cannot yet be confidently interpreted toward precise recommendations. Thus, nutritional advice for generally healthy individuals based on personal microbiome composition analysis might not yet be appropriate unless accompanied by established blood and physiological biomarkers.
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spelling pubmed-84212352021-09-09 Gut Microbiota–Informed Precision Nutrition in the Generally Healthy Individual: Are We There Yet? Nogal, Bartek Blumberg, Jeffrey B Blander, Gil Jorge, Milena Curr Dev Nutr PERSPECTIVES AND OPINIONS Since next generation sequencing facilitated high-throughput and cost-efficient genomics analyses, the human gut metagenome has become an emerging frontier to explore toward precision nutrition. Significant progress has been made in identifying gut microbial features associated with a wide spectrum of human disease. However, other than a few microbiome-disease relations, there is a dearth of confirmed causal inferences, particularly in generally healthy populations. The relatively high unexplained variability in microbiome compositions in this group warrants caution in applying this complex biomarker toward precision nutrition, because our understanding of what constitutes a healthy microbiome is still rudimentary. Although gut microbiota harbor integrated environmental and host-specific information with the potential to facilitate personalized nutritional and lifestyle advice, these data cannot yet be confidently interpreted toward precise recommendations. Thus, nutritional advice for generally healthy individuals based on personal microbiome composition analysis might not yet be appropriate unless accompanied by established blood and physiological biomarkers. Oxford University Press 2021-08-09 /pmc/articles/PMC8421235/ /pubmed/34514287 http://dx.doi.org/10.1093/cdn/nzab107 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle PERSPECTIVES AND OPINIONS
Nogal, Bartek
Blumberg, Jeffrey B
Blander, Gil
Jorge, Milena
Gut Microbiota–Informed Precision Nutrition in the Generally Healthy Individual: Are We There Yet?
title Gut Microbiota–Informed Precision Nutrition in the Generally Healthy Individual: Are We There Yet?
title_full Gut Microbiota–Informed Precision Nutrition in the Generally Healthy Individual: Are We There Yet?
title_fullStr Gut Microbiota–Informed Precision Nutrition in the Generally Healthy Individual: Are We There Yet?
title_full_unstemmed Gut Microbiota–Informed Precision Nutrition in the Generally Healthy Individual: Are We There Yet?
title_short Gut Microbiota–Informed Precision Nutrition in the Generally Healthy Individual: Are We There Yet?
title_sort gut microbiota–informed precision nutrition in the generally healthy individual: are we there yet?
topic PERSPECTIVES AND OPINIONS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421235/
https://www.ncbi.nlm.nih.gov/pubmed/34514287
http://dx.doi.org/10.1093/cdn/nzab107
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