Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation

The autoimmune regulator (AIRE) is essential for the establishment of central tolerance and prevention of autoimmunity. Interestingly, different AIRE mutations cause autoimmunity in either recessive or dominant-negative manners. Using engineered mouse models, we establish that some monoallelic mutan...

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Detalles Bibliográficos
Autores principales: Goldfarb, Yael, Givony, Tal, Kadouri, Noam, Dobeš, Jan, Peligero-Cruz, Cristina, Zalayat, Itay, Damari, Golda, Dassa, Bareket, Ben-Dor, Shifra, Gruper, Yael, Oftedal, Bergithe E., Bratland, Eirik, Erichsen, Martina M., Berger, Amund, Avin, Ayelet, Nevo, Shir, Haljasorg, Uku, Kuperman, Yael, Ulman, Adi, Haffner-Krausz, Rebecca, Porat, Ziv, Atasoy, Ulus, Leshkowitz, Dena, Husebye, Eystein S., Abramson, Jakub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421262/
https://www.ncbi.nlm.nih.gov/pubmed/34477806
http://dx.doi.org/10.1084/jem.20201076

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