Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome

Gain-of-function mutations in NLRP3 are responsible for a spectrum of autoinflammatory diseases collectively referred to as “cryopyrin-associated periodic syndromes” (CAPS). Treatment of CAPS patients with IL-1–targeted therapies is effective, confirming a central pathogenic role for IL-1β. However,...

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Detalles Bibliográficos
Autores principales: Stackowicz, Julien, Gaudenzio, Nicolas, Serhan, Nadine, Conde, Eva, Godon, Ophélie, Marichal, Thomas, Starkl, Philipp, Balbino, Bianca, Roers, Axel, Bruhns, Pierre, Jönsson, Friederike, Moguelet, Philippe, Georgin-Lavialle, Sophie, Broderick, Lori, Hoffman, Hal M., Galli, Stephen J., Reber, Laurent L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421266/
https://www.ncbi.nlm.nih.gov/pubmed/34477811
http://dx.doi.org/10.1084/jem.20201466

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