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Activation of AQP2 water channels by protein kinase A: therapeutic strategies for congenital nephrogenic diabetes insipidus
BACKGROUND: Congenital nephrogenic diabetes insipidus (NDI) is primarily caused by loss-of-function mutations in the vasopressin type 2 receptor (V2R). Renal unresponsiveness to the antidiuretic hormone vasopressin impairs aquaporin-2 (AQP2) water channel activity and water reabsorption from urine,...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Singapore
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421276/ https://www.ncbi.nlm.nih.gov/pubmed/34224008 http://dx.doi.org/10.1007/s10157-021-02108-6 |