The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling

Immunomodulatory drugs (IMiDs) are important for the treatment of multiple myeloma and myelodysplastic syndrome. Binding of IMiDs to Cereblon (CRBN), the substrate receptor of the CRL4(CRBN) E3 ubiquitin ligase, induces cancer cell death by targeting key neo-substrates for degradation. Despite this...

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Detalles Bibliográficos
Autores principales: Shen, Chen, Nayak, Anmada, Neitzel, Leif R., Adams, Amber A., Silver-Isenstadt, Maya, Sawyer, Leah M., Benchabane, Hassina, Wang, Huilan, Bunnag, Nawat, Li, Bin, Wynn, Daniel T., Yang, Fan, Garcia-Contreras, Marta, Williams, Charles H., Dakshanamurthy, Sivanesan, Hong, Charles C., Ayad, Nagi G., Capobianco, Anthony J., Ahmed, Yashi, Lee, Ethan, Robbins, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421366/
https://www.ncbi.nlm.nih.gov/pubmed/34489457
http://dx.doi.org/10.1038/s41467-021-25634-z

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