Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia

A subset of essential thrombocythemia (ET) cases are negative for disease-defining mutations on JAK2, MPL, and CALR and defined as triple negative (TN). The lack of recurrent mutations in TN-ET patients makes its pathogenesis ambiguous. Here, we screened 483 patients with suspected ET in a single in...

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Detalles Bibliográficos
Autores principales: Inano, Tadaaki, Araki, Marito, Morishita, Soji, Imai, Misa, Kihara, Yoshihiko, Okuda, Maho, Yang, Yinjie, Ito, Masafumi, Osaga, Satoshi, Mano, Hiroyuki, Edahiro, Yoko, Ochiai, Tomonori, Misawa, Kyohei, Fukuda, Yasutaka, Ando, Jun, Komatsu, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421373/
https://www.ncbi.nlm.nih.gov/pubmed/34489506
http://dx.doi.org/10.1038/s41598-021-97106-9

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