Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism

The endoplasmic-reticulum aminopeptidase ERAP1 processes antigenic peptides for loading on MHC-I proteins and recognition by CD8 T cells as they survey the body for infection and malignancy. Crystal structures have revealed ERAP1 in either open or closed conformations, but whether these occur in sol...

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Detalles Bibliográficos
Autores principales: Maben, Zachary, Arya, Richa, Georgiadis, Dimitris, Stratikos, Efstratios, Stern, Lawrence J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421391/
https://www.ncbi.nlm.nih.gov/pubmed/34489420
http://dx.doi.org/10.1038/s41467-021-25564-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421391/
https://www.ncbi.nlm.nih.gov/pubmed/34489420
http://dx.doi.org/10.1038/s41467-021-25564-w

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