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Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism

The endoplasmic-reticulum aminopeptidase ERAP1 processes antigenic peptides for loading on MHC-I proteins and recognition by CD8 T cells as they survey the body for infection and malignancy. Crystal structures have revealed ERAP1 in either open or closed conformations, but whether these occur in sol...

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Detalles Bibliográficos
Autores principales:	Maben, Zachary, Arya, Richa, Georgiadis, Dimitris, Stratikos, Efstratios, Stern, Lawrence J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421391/ https://www.ncbi.nlm.nih.gov/pubmed/34489420 http://dx.doi.org/10.1038/s41467-021-25564-w

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