A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci

Genome-wide association studies (GWAS) have identified many disease-associated variants, yet mechanisms underlying these associations remain unclear. To understand obesity-associated variants, we generate gene regulatory annotations in adipocytes and hypothalamic neurons across cellular differentiat...

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Detalles Bibliográficos
Autores principales: Joslin, Amelia C., Sobreira, Débora R., Hansen, Grace T., Sakabe, Noboru J., Aneas, Ivy, Montefiori, Lindsey E., Farris, Kathryn M., Gu, Jing, Lehman, Donna M., Ober, Carole, He, Xin, Nóbrega, Marcelo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421397/
https://www.ncbi.nlm.nih.gov/pubmed/34489471
http://dx.doi.org/10.1038/s41467-021-25614-3

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