Microglia have a grip on brain microvasculature

Microglia are brain resident immune cells with multiple functions. However, little is known about microglia-vascular interactions. In a recent paper published in Nature Communications, Bisht et al. identify a signalling mechanism that attracts and maintains microglia at the capillary wall. Moreover,...

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Autores principales: Kisler, Kassandra, Nikolakopoulou, Angeliki Maria, Zlokovic, Berislav V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421408/
https://www.ncbi.nlm.nih.gov/pubmed/34489417
http://dx.doi.org/10.1038/s41467-021-25595-3
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author Kisler, Kassandra
Nikolakopoulou, Angeliki Maria
Zlokovic, Berislav V.
author_facet Kisler, Kassandra
Nikolakopoulou, Angeliki Maria
Zlokovic, Berislav V.
author_sort Kisler, Kassandra
collection PubMed
description Microglia are brain resident immune cells with multiple functions. However, little is known about microglia-vascular interactions. In a recent paper published in Nature Communications, Bisht et al. identify a signalling mechanism that attracts and maintains microglia at the capillary wall. Moreover, they show that microglia regulate capillary vascular tone, playing a more significant role in blood flow regulation than previously thought.
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spelling pubmed-84214082021-09-22 Microglia have a grip on brain microvasculature Kisler, Kassandra Nikolakopoulou, Angeliki Maria Zlokovic, Berislav V. Nat Commun Comment Microglia are brain resident immune cells with multiple functions. However, little is known about microglia-vascular interactions. In a recent paper published in Nature Communications, Bisht et al. identify a signalling mechanism that attracts and maintains microglia at the capillary wall. Moreover, they show that microglia regulate capillary vascular tone, playing a more significant role in blood flow regulation than previously thought. Nature Publishing Group UK 2021-09-06 /pmc/articles/PMC8421408/ /pubmed/34489417 http://dx.doi.org/10.1038/s41467-021-25595-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Kisler, Kassandra
Nikolakopoulou, Angeliki Maria
Zlokovic, Berislav V.
Microglia have a grip on brain microvasculature
title Microglia have a grip on brain microvasculature
title_full Microglia have a grip on brain microvasculature
title_fullStr Microglia have a grip on brain microvasculature
title_full_unstemmed Microglia have a grip on brain microvasculature
title_short Microglia have a grip on brain microvasculature
title_sort microglia have a grip on brain microvasculature
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421408/
https://www.ncbi.nlm.nih.gov/pubmed/34489417
http://dx.doi.org/10.1038/s41467-021-25595-3
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