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Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion

The pyruvate dehydrogenase complex (PDHc) links glycolysis to the citric acid cycle by converting pyruvate into acetyl-coenzyme A. PDHc encompasses three enzymatically active subunits, namely pyruvate dehydrogenase, dihydrolipoyl transacetylase, and dihydrolipoyl dehydrogenase. Dihydrolipoyl transac...

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Detalles Bibliográficos
Autores principales:	Škerlová, Jana, Berndtsson, Jens, Nolte, Hendrik, Ott, Martin, Stenmark, Pål
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421416/ https://www.ncbi.nlm.nih.gov/pubmed/34489474 http://dx.doi.org/10.1038/s41467-021-25570-y

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