Cellular model system to dissect the isoform-selectivity of Akt inhibitors

The protein kinase Akt plays a pivotal role in cellular processes. However, its isoforms’ distinct functions have not been resolved to date, mainly due to the lack of suitable biochemical and cellular tools. Against this background, we present the development of an isoform-dependent Ba/F3 model syst...

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Detalles Bibliográficos
Autores principales: Quambusch, Lena, Depta, Laura, Landel, Ina, Lubeck, Melissa, Kirschner, Tonia, Nabert, Jonas, Uhlenbrock, Niklas, Weisner, Jörn, Kostka, Michael, Levy, Laura M., Schultz-Fademrecht, Carsten, Glanemann, Franziska, Althoff, Kristina, Müller, Matthias P., Siveke, Jens T., Rauh, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421423/
https://www.ncbi.nlm.nih.gov/pubmed/34489430
http://dx.doi.org/10.1038/s41467-021-25512-8

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