Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens

Chimeric antigen receptor (CAR) T cells have emerged as a promising class of therapeutic agents, generating remarkable responses in the clinic for a subset of human cancers. One major challenge precluding the wider implementation of CAR therapy is the paucity of tumor-specific antigens. Here, we des...

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Detalles Bibliográficos
Autores principales: Hwang, Michael S., Miller, Michelle S., Thirawatananond, Puchong, Douglass, Jacqueline, Wright, Katharine M., Hsiue, Emily Han-Chung, Mog, Brian J., Aytenfisu, Tihitina Y., Murphy, Michael B., Aitana Azurmendi, P., Skora, Andrew D., Pearlman, Alexander H., Paul, Suman, DiNapoli, Sarah R., Konig, Maximilian F., Bettegowda, Chetan, Pardoll, Drew M., Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Zhou, Shibin, Gabelli, Sandra B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421441/
https://www.ncbi.nlm.nih.gov/pubmed/34489470
http://dx.doi.org/10.1038/s41467-021-25605-4

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