GLCCI1 Deficiency Induces Glucocorticoid Resistance via the Competitive Binding of IRF1:GRIP1 and IRF3:GRIP1 in Asthma

GLCCI1 plays a significant role in modulating glucocorticoid (GC) sensitivity in asthma. This project determines the underlying mechanism that GLCCI1 deficiency attenuates GC sensitivity in dexamethasone (Dex)-treated Ovalbumin (OVA)-induced asthma mice and epithelial cells through upregulating bind...

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Detalles Bibliográficos
Autores principales: Hu, Xinyue, Deng, Shuanglinzi, Luo, Lisha, Jiang, Yuanyuan, Ge, Huan, Yin, Feifei, Zhang, Yingyu, Zhang, Daimo, Li, Xiaozhao, Feng, Juntao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421568/
https://www.ncbi.nlm.nih.gov/pubmed/34504850
http://dx.doi.org/10.3389/fmed.2021.686493

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