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First seroepidemiological investigation of human enterovirus 71 in Iran
BACKGROUND AND OBJECTIVES: Human Enterovirus 71 (EV-A71) is the causative agent for many dermal to neurological diseases especially polio-like paralysis outbreaks around the world. This study, the first of this kind in Iran, aimed to find neutralizing antibodies against EV-A71 in serum of healthy in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Tehran University of Medical Sciences
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421584/ https://www.ncbi.nlm.nih.gov/pubmed/34557279 http://dx.doi.org/10.18502/ijm.v13i4.6975 |
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author | Javadi, Mahsa Nejati, Ahmad Yousefi, Maryam Mahmoodi, Mahmood Shoja, Zabihollah Shahmahmoodi, Shohreh |
author_facet | Javadi, Mahsa Nejati, Ahmad Yousefi, Maryam Mahmoodi, Mahmood Shoja, Zabihollah Shahmahmoodi, Shohreh |
author_sort | Javadi, Mahsa |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: Human Enterovirus 71 (EV-A71) is the causative agent for many dermal to neurological diseases especially polio-like paralysis outbreaks around the world. This study, the first of this kind in Iran, aimed to find neutralizing antibodies against EV-A71 in serum of healthy individuals in different age groups based on neutralization test (NT). MATERIALS AND METHODS: In this cross-sectional study, 547 serum samples were collected from healthy individuals who were referring for routine checkup tests (aged from under 6 months to over 31 years old) to Imam-Khomeini Hospital in Tehran during January-December 2015. Serum samples were examined by NT in cell culture to detect neutralizing antibodies against EV-A71. In the next step, some of the positive samples were subjected to complete titration to determine the exact titer of anti-EV-A71 antibodies. RESULTS: Of 547 samples, 310 (56.7%) were positive for EV-A71 neutralizing antibody. The presence of the antibody increased with age (p<0.001), and there was a significant statistical relationship between sex and the presence of antibody (p=0.009). CONCLUSION: Our results demonstrated an apparent but limited circulation of EV-A71 in our society. After the worldwide eradication of poliovirus, EV-A71 which can cause polio-likes syndrome, might be the new challenge for our health care system as regard more in depth research is however needed. |
format | Online Article Text |
id | pubmed-8421584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-84215842021-09-22 First seroepidemiological investigation of human enterovirus 71 in Iran Javadi, Mahsa Nejati, Ahmad Yousefi, Maryam Mahmoodi, Mahmood Shoja, Zabihollah Shahmahmoodi, Shohreh Iran J Microbiol Original Article BACKGROUND AND OBJECTIVES: Human Enterovirus 71 (EV-A71) is the causative agent for many dermal to neurological diseases especially polio-like paralysis outbreaks around the world. This study, the first of this kind in Iran, aimed to find neutralizing antibodies against EV-A71 in serum of healthy individuals in different age groups based on neutralization test (NT). MATERIALS AND METHODS: In this cross-sectional study, 547 serum samples were collected from healthy individuals who were referring for routine checkup tests (aged from under 6 months to over 31 years old) to Imam-Khomeini Hospital in Tehran during January-December 2015. Serum samples were examined by NT in cell culture to detect neutralizing antibodies against EV-A71. In the next step, some of the positive samples were subjected to complete titration to determine the exact titer of anti-EV-A71 antibodies. RESULTS: Of 547 samples, 310 (56.7%) were positive for EV-A71 neutralizing antibody. The presence of the antibody increased with age (p<0.001), and there was a significant statistical relationship between sex and the presence of antibody (p=0.009). CONCLUSION: Our results demonstrated an apparent but limited circulation of EV-A71 in our society. After the worldwide eradication of poliovirus, EV-A71 which can cause polio-likes syndrome, might be the new challenge for our health care system as regard more in depth research is however needed. Tehran University of Medical Sciences 2021-08 /pmc/articles/PMC8421584/ /pubmed/34557279 http://dx.doi.org/10.18502/ijm.v13i4.6975 Text en Copyright © 2021 The Authors. Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited. |
spellingShingle | Original Article Javadi, Mahsa Nejati, Ahmad Yousefi, Maryam Mahmoodi, Mahmood Shoja, Zabihollah Shahmahmoodi, Shohreh First seroepidemiological investigation of human enterovirus 71 in Iran |
title | First seroepidemiological investigation of human enterovirus 71 in Iran |
title_full | First seroepidemiological investigation of human enterovirus 71 in Iran |
title_fullStr | First seroepidemiological investigation of human enterovirus 71 in Iran |
title_full_unstemmed | First seroepidemiological investigation of human enterovirus 71 in Iran |
title_short | First seroepidemiological investigation of human enterovirus 71 in Iran |
title_sort | first seroepidemiological investigation of human enterovirus 71 in iran |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421584/ https://www.ncbi.nlm.nih.gov/pubmed/34557279 http://dx.doi.org/10.18502/ijm.v13i4.6975 |
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